# US 9,751,852 B1 · Sulfoxide compound and method of producing benzothiophene derivatives using the same

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- Number: US 9,751,852 B1
- Document ID: US9751852B1
- Status: Granted
- Kind: B1
- Application number: 15/604,680
- Filed: 2017-05-25
- Granted: 2017-09-05
- Earliest claimed: 2016-12-01
- Assignees: National Sun Yat-Sen University
- Applicants: National Sun Yat-Sen University
- Inventors: Ming-Jung Wu; Shih-Ming Wen
- Web page: https://patentgrep.com/patent/US9751852B1

## CPC

- C07D 333/56: Radicals substituted by oxygen atoms
- C07C 317/22: with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C 323/20: with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A sulfoxide compound and method of producing benzothiophene derivatives using the same are provided. The sulfoxide compound is represented by formula (I), wherein R1 and R2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain; and X is halogen atom. The sulfoxide compound reacts with alkynyl compound, and then the synthesis efficiency of benzothiophene derivatives can be effectively increased.

## Claims

### Claim 1

A sulfoxide compound of formula (I)
wherein R1 and R2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain; and X is halogen atom.

### Claim 2 (depends on 1)

The compound of claim 1, wherein R1 and R2 are both methyl group.

### Claim 3 (depends on 1)

The compound of claim 1, wherein X is bromine atom.

### Claim 4 (depends on 1)

The compound of claim 1, wherein R1 is methyl group, and R2 is benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain.

### Claim 5 (depends on 1)

The compound of claim 1, wherein R1 is benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain, and R2 is methyl group.

### Claim 6 (depends on 1)

The compound of claim 1, wherein R1 and R2 are both methyl group, and X is bromine atom.

### Claim 7

A sulfide compound of formula (xii)
wherein R1 and R2 are individually and independently benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain; and X is halogen atom.

### Claim 8 (depends on 7)

The compound of claim 7, wherein R1 and R2 are both methyl group.

### Claim 9 (depends on 7)

The compound of claim 7, wherein X is bromine atom.

### Claim 10 (depends on 7)

The compound of claim 7, wherein R1 is methyl group, and R2 is benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain.

### Claim 11 (depends on 7)

The compound of claim 7, wherein R1 is benzoyl group; alkyl, acyl or silyl group of C1-C6 straight chain or branched chain; or alkenyl group of C3-C6 straight chain or branched chain, and R2 is methyl group.

### Claim 12 (depends on 7)

The compound of claim 7, wherein R1 and R2 are both methyl group, and X is bromine atom.