Precursor compound connected to solid support for manufacturing 18F radiopharmaceutical, method for manufacturing same, and application thereof

A solid precursor represented by Chemical Formula 1 below:

• wherein the solid support is an insoluble organic polymer selected from the group consisting of polystyrene, polyacrylate, polyacrylamide, polyacrylonitrile, polyethyleneglycol and mixtures thereof,
• wherein n is 1˜12,
• B is
• wherein R1 is a C1-C20 hydrocarbon group, and the hydrocarbon group includes one or more selected from the group consisting of nitrogen, oxygen and sulfur and is unsubstituted or substituted with a halogen, and R4 is a C1-C10 alkyl group,
• C is a single bond, —O—, or -D-SO2—O—, wherein D is —(CH2)n— (n is 1˜3) or
• and
• R is an organic group other than F-18 in an [18F]labeled radiopharmaceutical, and hydrogen in the organic group is unsubstituted or substituted with a protecting group
• X is methanesulfonate, trifluoromethanesulfonate, p-nitrobenzenesulfonate, tetrafluoroborate (BF4), hexafluorophosphate (PF6), hexafluoroantimonate (SbF6), bis(trifluoromethane) sulfonimide(N(Tf)2), sodium sulfate (NaSO4), potassium carbonate (KCO3), bicarbonate (HCO3), potassium hydrogen phosphate (KHPO4), dipotassium phosphate (K2PO4) or alkane sulfonate (R′SO3), wherein R′ is a C1-20 hydrocarbon group, and the C1-20 hydrocarbon group includes one or more selected from the group consisting of nitrogen, oxygen, sulfur, phosphorus and combinations thereof and is unsubstituted or substituted with a halogen.