# US 9,751,833 B2 · Antimicrobial biguanide metal complexes

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- Number: US 9,751,833 B2
- Document ID: US9751833B2
- Status: Granted
- Kind: B2
- Application number: 11/922,894
- Filed: 2006-06-27
- Published: 2009-05-14
- Granted: 2017-09-05
- Earliest claimed: 2005-06-27
- Assignees: Smith & Nephew, Inc.
- Applicants: Bryan Greener
- Inventors: Bryan Greener
- Web page: https://patentgrep.com/patent/US9751833B2

## CPC

- C07C 279/265: {containing two or more biguanide groups}
- A01N 59/16: Heavy metals; Compounds thereof
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- C07C 279/26: X and Y being nitrogen atoms, i.e. biguanides
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound comprising a metal species and a biologically acceptable ligand, wherein the biologically acceptable ligand comprises a biguanide moiety, and wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilised in an oxidation state greater than 1+. Compositions and medical devices comprising the compound. A method for the treatment or prophylaxis of microbial, including bacterial, infections, comprising the use of such compounds, compositions or medical devices.

## Claims

### Claim 1

A method for the treatment of microbial infections, comprising administering to an individual a compound comprising a metal species and a biologically acceptable ligand, wherein the metal species is selected from the group consisting of silver (III), copper (III), and gold (III); wherein the biologically acceptable ligand comprises a biguanide moiety; wherein the biologically acceptable ligand forms a complex with the metal species in which the metal species is stabilized in an oxidation state greater than 1+; and wherein the step of administering to an individual comprises contacting the individual with the compound.

### Claim 2 (depends on 1)

The method of claim 1, wherein contacting the individual with the compound comprises contacting the individual with a medical device comprising the compound.

### Claim 3 (depends on 1)

The method of claim 1, wherein the biologically acceptable ligand has the formula:
wherein R1, R2, and R3 are independently H or a hydrocarbyl group.

### Claim 4 (depends on 1)

The method of claim 1, wherein the biologically acceptable ligand has the formula:
wherein R1, R2, R3, and R4 are independently H or a hydrocarbyl group and R5 is a hydrocarbadiyl group.

### Claim 5 (depends on 1)

The method of claim 1, wherein the biologically acceptable ligand has the formula:
wherein R is a hydrocarbadiyl group and n is 1 or more.

### Claim 6 (depends on 1)

The method of claim 1, wherein the biologically acceptable ligand is selected from the group consisting of poly(hexamethylenebiguanide), chlorhexidine (1,1′-hexamethylenebis[5-(p-chlorophenyl)biguanide], metformin (N′, N′dimethylbiguanide), phenformin (phenethylbiguanide) and buformin (N-butylbiguanide).

### Claim 7 (depends on 2)

The method of claim 2, wherein the medical device comprises a wound or burn dressing, an implant, a scaffold for tissue repair, or a stent.