# US 9,750,954 B2 · Concurrent delivery of interstitial thermobrachytherapy (hyperthermia and brachytherapy) in the treatment of cancer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,954 B2 - Document ID: US9750954B2 - Status: Granted - Kind: B2 - Application number: 15/493,387 - Filed: 2017-04-21 - Published: 2017-08-03 - Granted: 2017-09-05 - Earliest claimed: 2008-10-28 - Assignees: The University of Toledo - Applicants: The University of Toledo - Inventors: E. Ishmael Parsai; Diana Shvydka; Gregory Warrell - Web page: https://patentgrep.com/patent/US9750954B2 ## CPC - A61N 5/1027: {Interstitial radiation therapy} - A61N 1/406: {using implantable thermoseeds or injected particles for localized hyperthermia (preparations of seeds and particles A61K41/0052)} - A61N 2005/1024: {Seeds} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties. ## Claims ### Claim 1 A brachytherapy seed comprising: a seed having within an interior space thereof a core comprising a ferromagnetic material; an electroplated conductive layer sheath on the surface of the core; and at least one layer comprising a radiation emission material that surrounds the core, wherein the radiation emission material comprises one or more of I-125, Pd-103, or Cs-131 radionuclides; and a metal shell surrounding the at least one layer comprising the radiation emission material; wherein no void exists between the core and the radiation emission material that surrounds the core. ### Claim 2 (depends on 1) The brachytherapy seed of claim 1, wherein the ferromagnetic material comprises a ferrite. ### Claim 3 (depends on 1) The brachytherapy seed of claim 1, wherein the seed exhibits a Curie point in a therapeutic range of from about 49° C. to about 60° C. ### Claim 4 (depends on 1) The brachytherapy seed of claim 1, wherein the electroplated conductive layer sheath comprises gold or copper. ### Claim 5 (depends on 1) The brachytherapy seed of claim 1, wherein the electroplated conductive layer sheath has a thickness of about 15 microns. ### Claim 6 (depends on 1) The brachytherapy seed of claim 1, wherein the ferromagnetic material comprises magnesium ferrite and copper. ### Claim 7 (depends on 1) The brachytherapy seed of claim 1, wherein the ferromagnetic material comprises Cu(0.5-x)MgxZn0.5Fe2O4, wherein x ranges from 0 to 0.5. ### Claim 8 (depends on 7) The brachytherapy seed of claim 7, wherein x is 0.25. ### Claim 9 (depends on 1) The brachytherapy seed of claim 1, wherein the ferromagnetic material comprises MnxZn(1-x)Fe2O4, wherein x ranges from 0 to 1. ### Claim 10 (depends on 9) The brachytherapy seed of claim 9, wherein x is about 0.32. ### Claim 11 (depends on 1) The brachytherapy seed of claim 1, wherein the ferromagnetic material comprises NiCu. ### Claim 12 (depends on 1) The brachytherapy seed of claim 1, wherein the ferromagnetic material comprises Ni0.72Cu0.28. ### Claim 13 (depends on 1) The brachytherapy seed of claim 1, wherein the electroplated conductive layer sheath is directly on the surface of the ferromagnetic material, and the at least one layer comprising a radiation emission material is directly on the electroplated conductive layer sheath. ### Claim 14 (depends on 1) The brachytherapy seed of claim 1, wherein the metal shell comprises Ti. ### Claim 15 A system, comprising: one or more implantable medical seeds, each implantable medical seed of the one or more implantable medical seeds including a body having an interior space and having at least one outer surface; one or more ferromagnetic energy-emitting elements comprising a ferromagnetic material positioned within the interior space of each said implantable medical seed, the one or more ferromagnetic energy-emitting elements configured to at least intermittently deliver a therapeutic dose of heat to tissue proximate to the at least one outer surface of each said implantable medical seed; and one or more radiation-emitting elements positioned within the interior space of each of the implantable medical seeds, the one or more radiation-emitting elements forming at least one layer that completely surrounds the one or more ferromagnetic energy-emitting elements positioned within the interior space of each said implantable medical seed, the one or more radiation-emitting elements configured to deliver a therapeutic dose of radiation to tissue proximate to the at least one outer surface of each said implantable medical seed; wherein the system is adapted to include a controller configured to apply an electro-magnetic or magnetic field to the one or more implantable medical seeds; and wherein no void exists between the ferromagnetic energy-emitting elements of each said implantable medical seed and the one or more radiation-emitting elements that surround the ferromagnetic energy-emitting elements. ### Claim 16 (depends on 15) The system of claim 15, wherein the ferromagnetic energy-emitting element is covered with an electroplated conductive layer sheath. ### Claim 17 (depends on 16) The system of claim 16, wherein the electroplated conductive layer sheath comprises gold or copper. ### Claim 18 (depends on 16) The system of claim 16, wherein the electroplated conductive layer sheath has a thickness of about 15 microns. ### Claim 19 (depends on 15) The system of claim 15, wherein the ferromagnetic material comprises magnesium ferrite and copper. ### Claim 20 (depends on 15) The system of claim 15, wherein the ferromagnetic material comprises Cu(0.5-x)MgxZn0.5Fe2O4, wherein x ranges from 0 to 0.5. ### Claim 21 (depends on 20) The system of claim 20, wherein x is 0.25. ### Claim 22 (depends on 15) The system of claim 15, wherein the ferromagnetic material comprises NiCu. ### Claim 23 (depends on 15) The system of claim 15, wherein the ferromagnetic material comprises Ni0.72Cu0.28. ### Claim 24 (depends on 1) A method of treating a subject in need thereof, the method comprising inserting at least one brachytherapy seed of claim 1 into the subject, and inducing a magnetic field applied to the brachytherapy seed to deliver a therapeutic dose of heat to tissue of the subject in proximity to the brachytherapy seed, wherein the brachytherapy seed also delivers a therapeutic dose of radiation to the tissue. ### Claim 25 (depends on 24) The method of claim 24, wherein the magnetic field strength is from about 2.5 kA/m to about 10 kA/m. ### Claim 26 (depends on 24) The method of claim 24, wherein the magnetic field oscillates at a frequency in the range of from about 50 kHz to about 200 kHz.