# US 9,750,952 B2 · Magnetic instrument for the homing of therapeutic cells and the elimination of excess therapeutic cells > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,952 B2 - Document ID: US9750952B2 - Status: Granted - Kind: B2 - Application number: 13/878,991 - Filed: 2011-10-19 - Published: 2013-10-03 - Granted: 2017-09-05 - Earliest claimed: 2010-10-19 - Assignees: Ogeno GmbH - Applicants: Ulrich Pison; Wolfgang Meissner; Michael Giersig - Inventors: Ulrich Pison; Wolfgang Meissner; Michael Giersig - Web page: https://patentgrep.com/patent/US9750952B2 ## CPC - A61N 2/004: {specially adapted for a specific therapy} - A61B 10/02: Instruments for taking cell samples or for biopsy {(A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48)} - A61N 2/02: using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) - A61N 2/06: using magnetic fields produced by permanent magnets (A61N2/12 takes precedence) - B03C 1/0332: {using permanent magnets} - B03C 1/286: {disposed at the inner circumference of a recipient, e.g. magnetic drain bolt} - G01N 33/54326: {Magnetic particles} - A61B 10/0045: {Devices for taking samples of body liquids} - A61B 10/0064: {for taking sweat or sebum samples (measuring sweat production A61B5/4266)} - A61B 10/04: Endoscopic instruments, e.g. catheter-type instruments - A61B 2010/0077: {Cerebrospinal fluid} - A61B 2017/00876: {magnetic} - B03C 2201/26: for use in medical or biological applications - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - B03C: MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS (separating isotopes B01D59/00; combinations of magnetic or electrostatic separation with separation of solids by other means B03B, B07B) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract The invention describes a system for the magnetic attraction of objects, which comprises a device with a magnetic element and at least one object having magnetic particles. ## Claims ### Claim 1 A method for magnetic attraction of therapeutic cells comprising: a. selecting therapeutic cells. b. labeling of the cells with magnetic particles to produce therapeutic labeled cells, c. introducing the therapeutic labeled cells according to b. into a body, d. introducing a device into the body wherein the device comprises: i. a guide element comprising a spring elastic distal area and a proximal area, ii. a magnetic function element which is introduced between the distal area and the proximal area of the guide element, and iii. a stabilizing element which is connected to the proximal area of the guide element and e. magnetically attracting and binding of the labeled therapeutic cells by the magnetic element of the device. ### Claim 2 (depends on 1) The method according to claim 1, wherein the therapeutic cells are magnetically attracted in a blood vessel system, efferent glandular ducts of the pancreatic gland, lacrimal gland, parotid gland, efferent glandular ducts of the mucous glands, mixed glands, skin and appendage glands, mammary glands, spinal canal, cerebral ventricle system, peridural space, gallbladder and its efferent anatomical structures, efferent urinary tract or a lymphatic system, body cavities of an abdomen, chest, uterus, urogenital apparatus or a joint or gastrointestinal tract. ### Claim 3 (depends on 1) The method of claim 1, wherein said method is configured for endoscopic administration, wherein the device further comprises: iv. an adapter and v. a longitudinally movable sleeve, wherein the magnetic function element comprises one or more magnetic elements having detection molecules, and endoscopically administering the therapeutic cells and magnetically attracting them via said one or more magnetic elements. ### Claim 4 (depends on 1) The method of claim 1, wherein the device is introduced into a vascular system via a vascular access. ### Claim 5 (depends on 1) The method of claim 1, wherein the therapeutic cells are magnetically attracted in course of a interventional treatment of disease selected from the group consisting of congenital diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, infectious diseases, hormonal diseases, diseases of blood and hematopoietic organs, diseases of the digestive tract, liver, the gallbladder, pancreatic gland, diseases of the urogenital tract and the kidneys, diseases of the heart, pathological changes in the blood vessel system and the lymphatic system, diseases of lungs, diseases of the central or peripheral nervous system and neurodegenerative diseases. ### Claim 6 (depends on 5) The method of claim 5, wherein the congenital diseases are selected from the group consisting of an autosomally recessive disease, an autosomally dominant disease, a gonosomal and mitochondrial and/or extrachromosomal disease or a disease that can be attributed to a genetic predisposition. ### Claim 7 (depends on 5) The method of claim 5, wherein the proliferative diseases are selected from the group consisting of a tumor, a precancerous condition, a dysplasia, a neuroendocrine tumor, an endometriosis and a metaplasia. ### Claim 8 (depends on 5) The method of claim 5, wherein the autoimmune diseases are selected from the group consisting of rheumatoid arthritis, inflammatory intestinal disease, osteoarthritis, neuropathic pain, alopecia areata, psoriasis, psoriatic arthritis, acute pancreatitis, allograft rejection, allergies, allergic inflammations of the lungs, multiple sclerosis, Alzheimer's disease, Crohn's disease and systemic lupus erythematosus. ### Claim 9 (depends on 5) The method of claim 5, wherein the infectious diseases are selected from the group consisting of a parasitic disease, a bacterial disease and a viral disease. ### Claim 10 (depends on 5) The method of claim 5, wherein the hormonal diseases are selected from the group consisting of a disease relating to sugar metabolism, fat metabolism, protein metabolism, sexual development and reproduction, water-salt balance, growth and cell production.