# US 9,750,923 B2 · Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients

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- Number: US 9,750,923 B2
- Document ID: US9750923B2
- Status: Granted
- Kind: B2
- Application number: 14/946,478
- Filed: 2015-11-19
- Published: 2016-05-19
- Granted: 2017-09-05
- Earliest claimed: 2014-11-19
- Assignees: Velóce Corporation
- Applicants: Nano Pharmaceutical Laboratories, LLC
- Inventors: Robert Niichel; Kevin McWilliams; John English; Amir H. Torbati; Christopher M. Yakacki
- Web page: https://patentgrep.com/patent/US9750923B2

## CPC

- A61B 5/6861: {Capsules, e.g. for swallowing or implanting}
- A61B 5/0002: {Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network (endoradiosondes A61B5/07)}
- A61B 5/061: {Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body (A61B1/00158 takes precedence)}
- A61B 5/4839: {combined with drug delivery}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 41/00: Medicinal preparations obtained by treating materials with wave energy or particle radiation {; Therapies using these preparations}
- A61K 41/0028: {Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds}
- A61M 37/00: Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04)
- A61M 2205/3523: using telemetric means
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Various embodiments of the present disclosure include a consumable capsule containing an active ingredient in at least one compartment movably sealed by a stimuli responsive actuator, and an activation device configured to communicate with the consumable capsule. The activation device is configured to emit a wireless signal to activate the stimuli responsive actuator of the consumable capsule, and the consumable capsule is configured to release the active ingredient into an external environment based on the activation of the stimuli responsive actuator.

## Claims

### Claim 1

A consumable capsule having an outer surrounding sidewall, comprising:
a signal receiving section comprising at least one coil configured to receive a wireless signal;
a control section configured to condition the wireless signal received by the at least one coil into a trigger signal for the consumable capsule;
a compartment section comprising at least one capsule compartment movably sealed by a stimuli responsive actuator, the compartment section being configured to activate the stimuli responsive actuator in response to the trigger signal from the control section to allow for release of an active ingredient contained in the at least one capsule compartment into an external environment
wherein the stimuli responsive actuator extends around the entire circumference of the outer surrounding sidewall and activation of the stimuli responsive actuator causes the stimuli responsive actuator to change shape in at least a radial direction and a longitudinal direction.

### Claim 2 (depends on 1)

The consumable capsule of claim 1, wherein the at least one stimuli responsive actuator comprises azobenzene incorporated in a liquid-crystalline elastomer.

### Claim 3 (depends on 1)

The consumable capsule of claim 1, wherein the compartment section further comprises a light source configured to emit light based at least in part on the trigger signal, and wherein the stimuli responsive actuator is activated based at least in part on the emitted light.

### Claim 4 (depends on 1)

The consumable capsule of claim 1, wherein the compartment section comprises at least two capsule compartments, the compartment section configured to simultaneously open the at least two capsule compartments.

### Claim 5 (depends on 1)

The consumable capsule of claim 1, wherein the compartment section comprises a plurality of capsule compartments, the compartment section being configured to sequentially open each capsule compartment of the plurality of capsule compartments.

### Claim 6 (depends on 1)

The consumable capsule of claim 1, wherein the control section comprises:
at least one rectifying circuit for rectifying the wireless signal, the rectifying circuit comprising at least one light emitting diode (LED), and
wherein the at least one LED is configured to activate the stimuli responsive actuator.

### Claim 7

A consumable capsule having an outer surrounding sidewall, comprising:
a signal receiving section comprising at least one coil configured to receive a wireless signal;
a control section configured to condition the wireless signal received by the at least one coil into a trigger signal for the consumable capsule;
a compartment section comprising at least one capsule compartment movably sealed by a stimuli responsive actuator, the compartment section being configured to activate the stimuli responsive actuator in response to the trigger signal from the control section to allow for release of an active ingredient contained in the at least one capsule compartment into an external environment
wherein the stimuli responsive actuator extends around the entire circumference of the outer surrounding sidewall and activation of the stimuli responsive actuator causes the stimuli responsive actuator to separate along a seam extending in a direction generally parallel to a longitudinal axis of the capsule.

### Claim 8 (depends on 7)

The consumable capsule of claim 7, wherein the at least one stimuli responsive actuator comprises azobenzene incorporated in a liquid-crystalline elastomer.

### Claim 9 (depends on 7)

The consumable capsule of claim 7, wherein the compartment section further comprises a light source configured to emit light based at least in part on the trigger signal, and wherein the stimuli responsive actuator is activated based at least in part on the emitted light.

### Claim 10 (depends on 7)

The consumable capsule of claim 7, wherein the compartment section comprises at least two capsule compartments, the compartment section configured to simultaneously open the at least two capsule compartments.

### Claim 11 (depends on 7)

The consumable capsule of claim 7, wherein the compartment section comprises a plurality of capsule compartments, the compartment section being configured to sequentially open each capsule compartment of the plurality of capsule compartments.

### Claim 12 (depends on 7)

The consumable capsule of claim 7, wherein the control section comprises:
at least one rectifying circuit for rectifying the wireless signal, the rectifying circuit comprising at least one light emitting diode (LED), and
wherein the at least one LED is configured to activate the stimuli responsive actuator.
