# US 9,750,846 B2 · Bioresorbable and biocompatible compounds for surgical use

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- Number: US 9,750,846 B2
- Document ID: US9750846B2
- Status: Granted
- Kind: B2
- Application number: 13/458,573
- Filed: 2012-04-27
- Published: 2012-11-01
- Granted: 2017-09-05
- Earliest claimed: 2007-09-07
- Assignees: Sofradim Production
- Applicants: Philippe Gravagna; Yves Bayon; Sebastien Ladet
- Inventors: Philippe Gravagna; Yves Bayon; Sebastien Ladet
- Web page: https://patentgrep.com/patent/US9750846B2

## CPC

- A61L 27/20: Polysaccharides
- A61L 27/24: Collagen
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan.

## Claims

### Claim 1

A compound comprising a functionalized collagen covalently bonded directly to chitosan without the use of a crosslinking agent, wherein the chitosan has a degree of acetylation from about 35 to 50% and wherein the collagen is functionalized by oxidative cleavage.

### Claim 2 (depends on 1)

A compound as in claim 1 wherein the functionalized collagen includes one or more reactive moieties selected from the group consisting of aldehydes, sulfones, vinylsulfones, isocyanates, and acid anhydrides.

### Claim 3 (depends on 1)

The compound of claim 1 wherein the functionalized collagen includes one or more reactive moieties selected from the group consisting of —CO2N(COCH2)2, —CO2N(COCH2)2, —CO2H, —CHO, —CHOCH2, —N═C═O, —SO2CH═CH2, —N(COCH)2, and —S—S—(C5H4N).

### Claim 4 (depends on 1)

The compound of claim 1 wherein the functionalized collagen is covalently bonded to at least a second chitosan with a degree of acetylation selected from about 0.5 to 60%.

### Claim 5

An implant comprising a compound containing a functionalized collagen covalently bonded directly to chitosan without the use of a crosslinking agent, wherein the chitosan has a degree of acetylation from about 35 to 50% and wherein the collagen is functionalized by oxidative cleavage.

### Claim 6 (depends on 5)

The implant of claim 5 comprising a sponge containing said compound.

### Claim 7 (depends on 5)

The implant of claim 5 comprising a textile containing said compound.

### Claim 8 (depends on 5)

The implant of claim 5 comprising a hydrogel containing said compound.

### Claim 9 (depends on 5)

The implant of claim 5 comprising threads containing said compound.

### Claim 10 (depends on 5)

The implant of claim 5 comprising a non knitted, non woven composite containing said compound.

### Claim 11 (depends on 5)

The implant of claim 5 comprising a film containing said compound.

### Claim 12 (depends on 5)

The implant of claim 5 comprising a mesh coated with a composition containing said compound.

### Claim 13

A method of forming a bioresorbable compound comprising contacting a functionalized collagen with a glycosaminoglycan without the use of a crosslinking agent, wherein the glycosaminoglycan is chitosan having a degree of acetylation from about 35% to 50% and wherein the collagen is functionalized by oxidative cleavage, wherein a deionized water solution of functionalized collagen is combined to a deionized water solution of chitosan having a degree of acetylation from about 35% to 50% to allow the functionalized collagen to mix with the chitosan and form said compound.

### Claim 14 (depends on 13)

The method of claim 13, wherein the pH of the solution of functionalized collagen is adjusted between 2 and 7.5.

### Claim 15 (depends on 13)

The method of claim 13, wherein the pH of the solution of glycosaminoglycan is adjusted between 2 and 7.5.

### Claim 16 (depends on 14)

The method of claim 14, wherein the pH of the solution of glycosaminoglycan is adjusted between 2 and 7.5.