# US 9,750,844 B2 · Composition for use in wound healing in burns

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- Number: US 9,750,844 B2
- Document ID: US9750844B2
- Status: Granted
- Kind: B2
- Application number: 14/857,189
- Filed: 2015-09-17
- Published: 2016-03-24
- Granted: 2017-09-05
- Earliest claimed: 2014-09-18
- Assignees: Academia Sinica; National Taiwan Ocean University
- Applicants: Academia Sinica; National Taiwan Ocean University
- Inventors: Jyh-Yih Chen; Chang-Jer Wu; Han-Ning Huang
- Web page: https://patentgrep.com/patent/US9750844B2

## CPC

- A61L 26/0047: {Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042}
- A61L 15/32: Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin {(A61L15/225 takes precedence)}
- A61L 15/325: {Collagen}
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61L 26/0033: {Collagen}
- A61L 26/0066: {Medicaments; Biocides}
- A61L 2300/252: Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/412: Tissue-regenerating or healing or proliferative agents
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

The preset invention relates to a new method for wound healing, particularly in burns, comprising Epinecidin-1 (Epi-1) or Pardaxin (GE33), optionally in the incorporation into collagen.

## Claims

### Claim 1

A method for preventing and treating MRSA infection in a burn wound comprising:
applying to the burn wound in a subject in need thereof, a composition comprising Epinecidin-1 (Epi-1) incorporated into collagen at a therapeutically effective amount to heal the burn wound, together with a pharmaceutically acceptable carrier, and
wherein Epi-1 consists of a peptide having the full length of the amino acid sequence of SEQ ID NO: 1.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the composition ameliorates excess recruitment of monocytes and macrophage cells, increases VEGF expression, and decreases immune responses.