Biodegradable medical adhesive and preparation method and use thereof
AssigneesInstitute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A., Chengdu Yiping Medical Science & Technology Co., Ltd.
InventorsKeliang Liu, Liang Xu, Qingsong Zhang, Dazhen Cai, Qingbin Meng
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Abstract
A medical adhesive with good biodegradable performance capable of undergoing crosslinking copolymerization, comprising a mono-alpha-cyanoacrylate and a bis-alpha-cyanoacrylic acid diol ester monomer molecule. The olefinic bonds in the mono-alpha-cyanoacrylate structure are polymerized in the presence of infinitesimal anions to form a solid 3D high polymer; the 3D high polymer is provided with degradation sites on the web-like backbone chain, with clear degradation path and absorbable degradation products. The medical adhesive can be used for wound adhesive, large area wound hemostasia, and visceral and soft tissue wound closure.
Claims11
A medical adhesive comprising a mono-α-cyanoacrylate and a bis-α-cyanoacrylic acid diol ester in a weight ratio of 1:1, wherein:
- 1) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG2000 ester and the mono-α-cyanoacrylate is n-butyl α-cyanoacrylate;
- 2) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG2000 ester and the mono-α-cyanoacrylate is n-octyl α-cyanoacrylate;
- or
- 3) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG600 ester and the mono-α-cyanoacrylate is n-butyl α-cyanoacrylate.
A method comprising the steps of:
- uniformly mixing a mono-α-cyanoacrylate and a bis-α-cyanoacrylic acid diol ester to form a medical adhesive in which the mono-α-cyanoacrylate and the bis-α-cyanoacrylic acid diol ester are in a weight ratio of 1:1, wherein:
- 1) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG2000 ester and the mono-α-cyanoacrylate is n-butyl α-cyanoacrylate;
- 2) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG2000 ester and the mono-α-cyanoacrylate is n-octyl α-cyanoacrylate;
- or
- 3) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG600 ester and the mono-α-cyanoacrylate is n-butyl α-cyanoacrylate.
A medical adhesive polymer, said medical adhesive polymer being obtained by crosslinking copolymerization of a medical adhesive under the action of anions, wherein the medical adhesive comprises a mono-α-cyanoacrylate and a bis-α-cyanoacrylic acid diol ester in a weight ratio of 1:1, wherein:
- 1) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG2000 ester and the mono-αcyanoacrylate is n-butyl α-cyanoacrylate;
- 2) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG2000 ester and the mono-α-cyanoacrylate is n-octyl α-cyanoacrylate;
- or
- 3) the bis-α-cyanoacrylic acid diol ester is bis-α-cyanoacrylic acid PEG600 ester and the mono-α-cyanoacrylate is n-butyl α-cyanoacrylate;
- and
- the anions are —OH or —NH2 in blood, body fluids, tissues, skin, or a combination thereof.
Dependencies are inferred from the claim text.