# US 9,750,828 B2 · Amorphous carbon supported nanoparticles comprising oxides of lanthanides and method for preparing them

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- Number: US 9,750,828 B2
- Document ID: US9750828B2
- Status: Granted
- Kind: B2
- Application number: 14/387,893
- Filed: 2013-03-27
- Published: 2015-11-12
- Granted: 2017-09-05
- Earliest claimed: 2012-03-29
- Assignees: BASF SE
- Applicants: BASF Corporation
- Inventors: Jacobus Hoekstra; Eefjan Breukink; Leonardus Wijnand Jenneskens; John Wilhelm Geus
- Web page: https://patentgrep.com/patent/US9750828B2

## CPC

- A61K 51/1251: {micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules}
- A61K 51/1244: {microparticles or nanoparticles, e.g. polymeric nanoparticles}
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 13/12: of the kidneys
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention is directed to bodies comprising an amorphous carbon particle on which are supported nanoparticles of an oxide of lanthanide. These bodies find use as a pharmaceutical for use in a surgery or therapy and diagnostic methods. The bodies can be made by a process comprising impregnating a carbon source material by contacting it with a solution of a salt of the lanthanide; drying the impregnated carbon source material; and subjecting the dried impregnated material to pyrolysis under inert conditions.

## Claims

### Claim 1

A body comprising a porous amorphous carbon particle impregnated with nanoparticles consisting essentially of an oxide of lanthanide, the body having a diameter of 10-1000 micrometers.

### Claim 2 (depends on 1)

The body according to claim 1, wherein the oxide of lanthanide nanoparticles have a diameter of 10 nm or less.

### Claim 3 (depends on 1)

The body according to claim 1, wherein the oxide of lanthanide nanoparticles have a diameter of 5 nm or less.

### Claim 4 (depends on 1)

The body according to claim 1, wherein the oxide of lanthanide is holmium oxide.

### Claim 5 (depends on 4)

The body according to claim 4, wherein the oxide of lanthanide is Ho2O3.

### Claim 6 (depends on 1)

The body according to claim 1, wherein the body is substantially spherical.

### Claim 7 (depends on 1)

The body according to claim 1, having a diameter of 15-500 μm.

### Claim 8 (depends on 1)

The body according to claim 1, having a diameter of 20-400 μm.

### Claim 9 (depends on 1)

The body according to claim 1, having a diameter of 25-250 μm.

### Claim 10 (depends on 1)

The body according to claim 1, wherein the body further comprises attached to its surface one or more active groups selected from the group consisting of nucleic acids, lipids, fatty acids, carbohydrates, polypeptides, amino acids, proteins, plasma, antibodies, antigens, liposomes, hormones, markers and combinations thereof.

### Claim 11 (depends on 1)

The body according to claim 1, wherein the body further comprises attached to its surface one or more antibodies.

### Claim 12 (depends on 1)

A method for treating a disorder comprising: treating a human or an animal body in a surgery, therapy, or diagnostic methods practiced on the human or animal body, with the amorphous carbon particle of claim 1.

### Claim 13 (depends on 12)

The method according to claim 12, wherein the therapy comprises radiotherapy.

### Claim 14 (depends on 13)

The method according to claim 13, wherein the radiotherapy comprises radio-embolization.

### Claim 15 (depends on 13)

The method according to claim 13, wherein the disorder comprises liver disorders or kidney disorders.

### Claim 16 (depends on 13)

The method according to claim 13, wherein the disorder comprises a tumor.

### Claim 17 (depends on 13)

The method according to claim 13, wherein the disorder comprises metastases.