# US 9,750,825 B2 · Multiphase oral care compositions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,825 B2 - Document ID: US9750825B2 - Status: Granted - Kind: B2 - Application number: 14/365,113 - Filed: 2011-12-16 - Published: 2014-11-20 - Granted: 2017-09-05 - Earliest claimed: 2011-12-16 - Assignees: Colgate-Palmolive Company - Applicants: Gregory Szewczyk; Neeta Atul Patel; Suzanne Jogun; Michael Prencipe - Inventors: Gregory Szewczyk; Neeta Atul Patel; Suzanne Jogun; Michael Prencipe - Web page: https://patentgrep.com/patent/US9750825B2 ## CPC - A61K 49/00: Preparations for testing in vivo - A61K 8/0204: {Specific forms not provided for by any of groups A61K8/0208 - A61K8/14} - A61K 8/0233: {Distinct layers, e.g. core/shell sticks} - A61K 8/345: {containing more than one hydroxy group} - A61K 8/4993: {Derivatives containing from 2 to 10 oxyalkylene groups} - A61K 8/731: {Cellulose; Quaternized cellulose derivatives} - A61K 8/732: {Starch; Amylose; Amylopectin; Derivatives thereof} - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - B65D 35/00: Pliable tubular containers adapted to be permanently {or temporarily} deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor - A61K 2800/43: Pigments; Dyes - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - B65D: CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES ## Abstract Described herein are dentifrices comprising a first formulation and a second formulation, wherein the formulations are coaxially extruded, so that the first formulation enrobes the second formulation, wherein the first formulation is opaque and wherein the second formulation comprises dissolvable film fragments, together with methods of making and using the same and containers for providing the same. ## Claims ### Claim 1 A dentifrice comprising a first formulation and a second formulation, wherein the formulations are coaxially extruded, so that the first formulation enrobes the second formulation, wherein the first formulation is opaque and wherein the second formulation comprises dissolvable film fragments; wherein the film fragments are stable in the formulation but disintegrate during use of the dentifrice and wherein the film fragments comprise a pigment that is released upon disintegration of the film fragments during use of the dentifrice; and wherein the film fragments comprise by dry weight of the film, 20-60% cellulose ethers, 10-30% propylene glycol, 1-5% polysorbate 80, and 15-55% pigment; and wherein the film fragments are single layer film fragments. ### Claim 2 (depends on 1) The dentifrice of claim 1 wherein the cellulose ether is selected from the group consisting of an alkylcellulose, a hydroxyalkyl cellulose, and a combination of two or more thereof. ### Claim 3 (depends on 1) The dentifrice of claim 1 wherein the film fragments further comprise a starch. ### Claim 4 (depends on 1) The dentifrice of claim 1 wherein the film fragments are substantially dissolved after a period of greater than 30 seconds and less than 180 seconds of brushing in the presence of water, thereby providing a color signal to the user of adequate brushing. ### Claim 5 (depends on 1) The dentifrice of claim 1 wherein the average thickness of the film fragments is 0.5-5 mils. ### Claim 6 (depends on 1) The dentifrice of claim 1 wherein the cellulose ethers are selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, and mixtures thereof. ### Claim 7 (depends on 1) The dentifrice of claim 1 further comprising one or more of water, abrasives, surfactants, foaming agents, vitamins, polymers, enzymes, humectants, thickeners, antimicrobial agents, preservatives, flavorings, colorings and/or combinations thereof. ### Claim 8 (depends on 1) The dentifrice of claim 1 wherein the first formulation has a water activity higher than the water activity of the second formulation. ### Claim 9 A dentifrice comprising a first formulation and a second formulation, wherein the formulations are coaxially extruded, so that the first formulation enrobes the second formulation, wherein the first formulation comprises dissolvable film fragments and the second formulation is opaque. ### Claim 10 (depends on 1) A toothpaste container capable of co-axial extrusion of a first dentifrice formulation which is opaque and a second dentifrice formulation which comprises film fragments, such that upon extrusion, the first formulation enrobes the second formulation, to provide a dentifrice according to claim 1, the toothpaste container having an aperture, a first zone or compartment within the container containing the first dentifrice formulation, and a second zone or compartment within the container containing the second dentifrice formulation, wherein the aperture is adapted for coaxial extrusion and has an outer opening in fluid communication with the first zone or compartment, said outer opening being coaxially oriented around a central opening in fluid communication with the second zone or compartment, and wherein the volume of the first and second zones or compartments can be reduced, such that when the volume of first and second zones or compartments is reduced, the first and second formulations are coaxially extruded from the aperture. ### Claim 11 (depends on 1) A method of cleaning the teeth comprising brushing with a dentifrice according to claim 1 wherein the film fragments comprise a pigment and brushing is continued until the film fragments dissolve and the pigment provides a color signal to the user of adequate brushing. ### Claim 12 (depends on 1) A method of making a dentifrice according to claim 1 comprising coaxially extruding a first formulation and a second formulation, so that the first formulation enrobes the second formulation.