# US 9,750,818 B2 · Targeted conjugates and particles and formulations thereof

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- Number: US 9,750,818 B2
- Document ID: US9750818B2
- Status: Granted
- Kind: B2
- Application number: 15/382,487
- Filed: 2016-12-16
- Published: 2017-04-06
- Granted: 2017-09-05
- Earliest claimed: 2014-06-30
- Assignees: Tarveda Therapeutics, Inc.
- Applicants: Tarveda Therapeutics, Inc.
- Inventors: Rossitza G. Alargova; Mark T. Bilodeau; Craig A. Dunbar; Sudhakar Kadiyala; Rajesh R. Shinde; Patrick Lim Soo; Beata Sweryda-Krawiec; Brian H. White; Patrick Rosaire Bazinet; Richard Wooster
- Web page: https://patentgrep.com/patent/US9750818B2

## CPC

- A61K 47/64: Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers A61K47/65)
- A61K 31/337: having four-membered rings, e.g. taxol
- A61K 31/5383: ortho- or peri-condensed with heterocyclic ring systems
- A61K 47/55: the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
- A61K 47/65: Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
- A61P 35/00: Antineoplastic agents
- A61P 35/02: specific for leukemia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

## Claims

### Claim 1

A conjugate having a structure of
or a salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising the conjugate of claim 1 or a salt thereof, and at least one pharmaceutically acceptable carrier or excipient.