Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these viruses
AssigneeStichting Wageningen Research
InventorsJeroen Alexander Kortekaas, Paulus-Jozef Wichgers Schreur, Nadia Dimitrova Oreshkova, Robertus Jacobus Maria Moormann
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Abstract
The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.
Claims18
A bunyavirus of the genus Phlebovirus, in which separated Gn and Gc coding regions, or separated NSmGn and Gc coding regions, are functionally present on two separate genome segments.
A method for generating a bunyavirus of the genus Phlebovirus, the method comprising:
- A) providing a cell with a bunyavirus of the genus Phlebovirus comprising at least one genome segment functionally encoding a RdRp gene and an N gene, and
- B) providing the cell with at least two genome segments selected from L, M, and S genome segments in which separated Gn and Gc coding regions, or separated NSmGn and Gc coding regions, are functionally present on two separate genome segments.
Dependencies are inferred from the claim text.