# US 9,750,781 B2 · Decubitus treatment system

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- Number: US 9,750,781 B2
- Document ID: US9750781B2
- Status: Granted
- Kind: B2
- Application number: 14/579,190
- Filed: 2014-12-22
- Published: 2015-05-21
- Granted: 2017-09-05
- Earliest claimed: 2012-10-02
- Assignees: Aloe Bioscience, LLC
- Applicants: Aloe Bioscience, LLC
- Inventors: Ivan E. Danhof
- Web page: https://patentgrep.com/patent/US9750781B2

## CPC

- A61K 36/886: Aloeaceae (Aloe family), e.g. aloe vera
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K 47/14: Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- Y10S 435/81: Packaged device or kit
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The present invention includes compositions and methods for cleaning, treating, protection and resolution of decubitus ulcers comprising: a first composition comprising a wound cleaning solution comprising aloe vera gel comprising at least 5,000 MPS, a balanced salt solution; and a second composition comprising a wound healing gel comprising aloe vera gel comprising at least 10,000 MPS, a thickening agent, and one or more preservatives and, optionally, a third composition comprising a moisture barrier cream comprising a vegetable-based emulsifier, a cosmetic ester for dry skin that has low occlusivity, an ester-based emollient that is oxidation stable and has low occlusivity; a beeswax; a hydrogenated oil, glycerin, a buffering agent, aloe vera gel comprising at least 2,000 MPS and water.

## Claims

### Claim 1

A method of cleaning and treating decubitus ulcers comprising:
identifying a subject in need thereof of treatment of one or more decubitus ulcers;
cleaning the one or more decubitus ulcers with a first composition comprising an aloe vera mucopolysaccharide gel having an average molecular weight distribution for long-chain polysaccharides of 5,000 saccharides per chain, and a balanced salt solution; and
coating the one or more decubitus ulcers with a second composition comprising aloe vera mucopolysaccharide gel having an average molecular weight distribution for long-chain polysaccharides of 10,000 saccharides per chain, a thickening agent, and one or more preservatives.

### Claim 2 (depends on 1)

The method of claim 1, further comprising the step of providing the one or more decubitus ulcers with a moisture barrier with a third composition comprising a moisture barrier cream comprising a vegetable-based emulsifier, a cosmetic ester for dry skin that has low occlusivity, an ester-based emollient that is oxidation stable and has low occlusivity; a beeswax; a hydrogenated castor oil, glycerin, a buffering agent, aloe vera gel comprising at least 2,000 MPS and water.

### Claim 3 (depends on 1)

The method of claim 1, wherein the balanced salt solution comprises: NaCl, KCl, CaCl2, NaHCO3 and Na2HPO4 adjusted to pH 4.5.

### Claim 4 (depends on 1)

The method of claim 1, wherein the thickening agent comprises at least one of xanthan gum, guar gum or locust bean gum.

### Claim 5 (depends on 1)

The method of claim 1, wherein one or more preservatives comprise benzoate salts, benzonium salts, or sorbate salts.

### Claim 6 (depends on 2)

The method of claim 2, wherein the vegetable based emulsifier comprises a Diisostearoyl Polyglyceryl-3 Dimer Dilinoleate, a Polyglyceryl-4 Isostearate, a Polyglyceryl-4 Diisostearate, a Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate or a Polyglyceryl-3 Oleate.

### Claim 7 (depends on 1)

The method of claim 1, wherein the cosmetic ester for dry skin that has low occlusivity is cetearyl ethylhexanoate.

### Claim 8 (depends on 1)

The method of claim 1, wherein the ester-based emollient that is oxidation stable and has low occlusivity is isocetyl Palmitate.

### Claim 9 (depends on 1)

The method of claim 1, wherein the hydrogenated oil is hydrogenated castor oil.