# US 9,750,775 B2 · Lactic acid bacterium-containing preparation

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- Number: US 9,750,775 B2
- Document ID: US9750775B2
- Status: Granted
- Kind: B2
- Application number: 14/707,521
- Filed: 2015-05-08
- Published: 2015-08-27
- Granted: 2017-09-05
- Earliest claimed: 2010-03-10
- Assignees: Kaneka Corporation
- Applicants: Kaneka Corporation
- Inventors: Airo Tategaki; Toyoaki Watanabe; Kazuya Hamada
- Web page: https://patentgrep.com/patent/US9750775B2

## CPC

- A61K 35/744: Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61P 3/06: Antihyperlipidemics
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- C12N 1/205: Bacterial isolates
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2400/413: Acidilactici
- C12R 2001/01: Bacteria or Actinomycetales {; using bacteria or Actinomycetales}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

The present invention provides very safe lactic acid bacteria and lactic acid bacteria preparations which are effective in prevention and therapy of allergies and/or in lowering of the blood neutral fat level. The present invention also provides pharmaceutical products and food or drink products which contain, as an active ingredient, a composition that contains cultured cells of the lactic acid bacterium Pediococcus acidilactici R037 or a treated product thereof.

## Claims

### Claim 1

A method for lowering neutral fat in blood of a hypertriglyceridemia patient or an individual at high risk of hypertriglyceridemia, comprising administering a strain of a lactic acid bacterium Pediococcus acidilactici R037 (NITE BP-900) or a
product obtained from the lactic acid bacterium by grinding or disrupting or a treated product that has been subjected to at least one treatment selected from the group consisting of concentration, conversion into a paste, drying and dilution of the lactic acid bacterium, in a single dose or multiple doses such that a daily intake of the lactic acid bacterium or the product obtained from the lactic acid bacterium by a target adult person is 0.01 to 1000 mg/kg body weight per day.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the daily intake of the lactic acid bacterium or the product obtained from the lactic acid bacterium by the target adult person is 0.1 to 500 mg/kg body weight per day.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the composition is in the form of a food and the amount of the lactic acid bacterium Pediococcus acidilactici R037 (NITE BP-900) or the product obtained from the lactic acid bacterium is 0.001 to 50% by weight of the food.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the composition further comprises an excipient.

### Claim 5 (depends on 4)

The method according to claim 4, wherein the amount of the excipient in the composition is 33 to 90% by weight.

### Claim 6 (depends on 2)

The method according to claim 2, wherein the composition further comprises an excipient.

### Claim 7 (depends on 6)

The method according to claim 6, wherein the amount of the excipient in the composition is 33 to 90% by weight.

### Claim 8 (depends on 3)

The method according to claim 3, wherein the composition further comprises an excipient.

### Claim 9 (depends on 8)

The method according to claim 8, wherein the amount of the excipient in the composition is 33 to 90% by weight.