# US 9,750,764 B2 · Trace elements > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,764 B2 - Document ID: US9750764B2 - Status: Granted - Kind: B2 - Application number: 13/130,336 - Filed: 2009-11-30 - Published: 2012-05-24 - Granted: 2017-09-05 - Earliest claimed: 2008-12-09 - Assignees: Warburton Technology Limited - Applicants: William Alfred Smith - Inventors: William Alfred Smith - Web page: https://patentgrep.com/patent/US9750764B2 ## CPC - A61K 33/34: Copper; Compounds thereof - A23K 20/30: {Oligoelements} - A23K 50/10: for ruminants - A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof - A61K 33/18: Iodine; Compounds thereof - A61K 33/24: Heavy metals; Compounds thereof - A61K 33/30: Zinc; Compounds thereof - A61K 33/32: Manganese; Compounds thereof - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 3/02: Nutrients, e.g. vitamins, minerals - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23K: FODDER - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract The inventions discloses a trace element solution, which comprises at least the following metals: zinc; manganese; selenium; and copper; and which comprises a concentration of the metals of at least 90 mg/ml. The solution may comprise the following concentrations: at least 60 mg/ml zinc; at least 10 mg/ml manganese; at least 5 mg/ml selenium; and at least 15 mg/ml copper. The solution may comprise chromium, iodine and chromium. ## Claims ### Claim 1 A method of preparing a trace element solution with a concentration of the metals of at least 90 mg/ml, said method comprising: (a) heating water; (b) adding manganese carbonate to the water wherein manganese sulphate and sodium carbonate are not used in situ manufacture of the manganese carbonate; (c) adding zinc oxide to the water; (d) adding copper carbonate to the water to form a liquid mixture; (e) adding a dry mixture comprising ethylene diaminotetraacetic acid (EDTA) and/or ethylenediamine-N,N′-disuccinic acid (EDDS) and NaOH to the liquid mixture; and (f) adding Na2SeO3 to form the trace element solution with a concentration of metals of at least 90 mg/ml, wherein the trace element solution has at least 60 mg/ml zinc. ### Claim 2 (depends on 1) The method as claimed in claim 1, in which in step (a) the water is heated to 70° C. ### Claim 3 (depends on 1) The method as claimed in claim 1, in which step (e) occurs slowly to prevent excessive frothing. ### Claim 4 (depends on 1) The method as claimed in claim 1, further comprising adding chloro-cresol to the solution and stirred until dissolved. ### Claim 5 (depends on 1) The method as claimed in claim 1, in which the pH of the solution is adjusted. ### Claim 6 (depends on 1) The method as claimed in claim 1, further comprises adding CrCl3.6H2O to the trace element solution. ### Claim 7 (depends on 1) The method as claimed in claim 1, further comprises adjusting the pH of the trace element solution to 6.0 to 8.0. ### Claim 8 (depends on 1) The method as claimed in claim 1, further comprises adjusting the pH of the trace element solution by adding at least one compound selected from the group consisting of NaOH and EDTA. ### Claim 9 (depends on 1) The method as claimed in claim 1 further comprises cooling the trace element solution prior to addition of the Na2SeO3. ### Claim 10 (depends on 1) The method as claimed in claim 1, which is a batch process. ### Claim 11 (depends on 1) A trace element solution which is prepared by the method as claimed in claim 1. ### Claim 12 A method of preparing a trace element solution with a concentration of metals being at least 90 mg/ml, said method consisting essentially of the steps of: (a) heating water; (b) adding manganese carbonate to the water wherein manganese sulphate and sodium carbonate are not used in situ manufacture of the manganese carbonate; (c) adding zinc oxide to the water; (d) adding copper carbonate to the water to form a liquid mixture; (e) adding a dry mixture comprising ethylene diaminotetraacetic acid (EDTA) and/or ethylenediamine-N,N′-disuccinic acid (EDDS) and NaOH to the liquid mixture; and (f) adding Na2SeO3 to form the trace element solution having at least 90 mg/ml of metals, wherein the trace element solution has at least 60 mg/ml zinc. ### Claim 13 (depends on 11) The trace elements solution of claim 11, wherein the metals have the following concentrations: (a) at least 10 mg/ml manganese; (b) at least 5 mg/ml selenium; and (c) at least 15 mg/ml copper. ### Claim 14 (depends on 11) The trace elements solution of as claimed in claim 11, in which the ratio of zinc to manganese is at least 2:1. ### Claim 15 (depends on 11) The trace elements solution of claim 11, in which the ratio of zinc to manganese is at least 4:1. ### Claim 16 (depends on 11) The trace elements solution of claim 11, in which the ratio of zinc to copper is at least 2:1 or 4:1. ### Claim 17 (depends on 11) The trace elements solution of claim 11, in which the ratio of zinc to selenium is at least 4:1 or 12:1. ### Claim 18 (depends on 11) The trace elements solution of claim 11, in which at least one of the metals is provided in the form of an ethylene diaminotetraacetic acid (EDTA) complex and/or an ethylenediamine-N,N′-disuccinic acid (EDDS) complex. ### Claim 19 (depends on 17) The trace elements solution of claim 17, in which the EDTA source is EDTA acid, disodium EDTA, tetra-sodium EDTA, calcium EDTA, potassium EDTA and/or any other EDTA source. ### Claim 20 (depends on 12) A trace element solution with a concentration of the metals of at least 90 mg/ml, produced by the method of claim 12. ### Claim 21 (depends on 20) The trace elements solution of claim 20, wherein the metals have the following concentrations: (a) at least 10 mg/ml manganese; (b) at least 5 mg/ml selenium; and (c) at least 15 mg/ml copper. ### Claim 22 (depends on 20) The trace elements solution of claim 20, in which the ratio of zinc to manganese is at least 2:1. ### Claim 23 (depends on 20) The trace elements solution of claim 20, in which the ratio of zinc to manganese is at least 4:1. ### Claim 24 (depends on 20) The trace elements solution of claim 20, in which the ratio of zinc to copper is at least 2:1 or 4:1. ### Claim 25 (depends on 20) The trace elements solution of claim 20, in which the ratio of zinc to selenium is at least 4:1 or 12:1. ### Claim 26 (depends on 20) The trace elements solution of claim 20, in which at least one of the metals is provided in the form of an ethylene diaminotetraacetic acid (EDTA) complex and/or an ethylenediamine-N,N′-disuccinic acid (EDDS) complex. ### Claim 27 (depends on 26) The trace elements solution of claim 26, in which the EDTA source is EDTA acid, disodium EDTA, tetra-sodium EDTA, calcium EDTA, potassium EDTA and/or any other EDTA source.