# US 9,750,755 B2 · Antimicrobial compositions and related methods

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- Number: US 9,750,755 B2
- Document ID: US9750755B2
- Status: Granted
- Kind: B2
- Application number: 14/741,701
- Filed: 2015-06-17
- Published: 2015-10-01
- Granted: 2017-09-05
- Earliest claimed: 2006-09-08
- Assignees: DeLaval Holding AB
- Applicants: DeLaval Holding AB
- Inventors: Fahim U. Ahmed; Alex Skender; Chris Foret; Thomas C. Hemling; N. Camelia Traistaru
- Web page: https://patentgrep.com/patent/US9750755B2

## CPC

- A61K 31/60: Salicylic acid; Derivatives thereof
- A01N 37/02: Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
- A61K 9/0017: {Non-human animal skin, e.g. pour-on, spot-on}
- A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)}
- A61K 31/095: Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60)
- A61K 31/191: having two or more hydroxy groups, e.g. gluconic acid
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K 31/201: having one or two double bonds, e.g. oleic, linoleic acids
- A61K 31/375: Ascorbic acid, i.e. vitamin C; Salts thereof
- A61K 47/08: containing oxygen, {e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/20: containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

A liquid antimicrobial composition comprising an organic acid and one or more anionic surfactants is disclosed. In one embodiment, the organic acid is lactic acid and the anionic surfactant is sodium octane sulfonate. In a preferred embodiment, the antimicrobial solution is formulated as a teat dip for lactating animals, particularly cows. In other embodiments, the antimicrobial compositions may be used in personal care, hard surface care including hard surface disinfection in households, food processing, hospitals, restaurants, hotels, showers, or topically as hand soaps, surgical scrubs, and hoof disease mitigators.

## Claims

### Claim 1

A method for controlling bovine mastitis in a bovine in need thereof comprising contacting the teats of a bovine with a nonirritating teat dip composition that consists essentially of
about 0.02 to 30% w/w lactic acid;
about 0.02 to 30% w/w Sodium Octane Sulfonate; an anionic surfactant; and
an alkaline pH adjusting agent,
wherein said composition has a half haemolysis (H50) value of at least 500 ppm, a Lysis/Denaturation (L/D) ratio greater than 100, and a pH ranging from 1.0 to about 5.0.

### Claim 2 (depends on 1)

The method of claim 1, wherein the anionic surfactant is selected from the group consisting of:
alkyl sulfonates, secondary alkane sulfonates, alkyl sulfates, alkyl ether sulfates, aryl sulfonates, aryl sulfates, alkylaryl sulfonates, alkylaryl sulfates, alkyl ether sulfonates and alkaline earth and ammonium salts and combinations thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein the anionic surfactant is selected from the group consisting of:
alkali lauryl sulfates, alkali dodecylbenzenesulfonates, alkali octane sulfonates, alkali secondary alkane sulfonates and alkali lauryl ether sulfates and alkaline earth and ammonium salts thereof.

### Claim 4 (depends on 2)

The method of claim 2, wherein said anionic surfactant is Sodium Secondary Alkane Sulfonate.

### Claim 5 (depends on 3)

The method of claim 3, wherein said anionic surfactant is Sodium Lauryl Sulphate (SLS).

### Claim 6 (depends on 1)

The method of claim 1, wherein said composition is characterized by a Lysis/Denaturation (L/D) ratio greater than 355.39.