# US 9,750,750 B2 · Compositions and methods for stimulating hair growth

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- Number: US 9,750,750 B2
- Document ID: US9750750B2
- Status: Granted
- Kind: B2
- Application number: 14/727,104
- Filed: 2015-06-01
- Published: 2015-11-19
- Granted: 2017-09-05
- Earliest claimed: 2009-11-09
- Assignees: Allergan, Inc.
- Applicants: Allergan, Inc.
- Inventors: John T. Trogden; Adnan K. Salameh; Chetan P. Pujara
- Web page: https://patentgrep.com/patent/US9750750B2

## CPC

- A61K 31/5575: having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A61K 8/0216: {Solid or semisolid forms}
- A61K 8/022: {Powders; Compacted Powders}
- A61K 8/042: {Gels}
- A61K 8/046: {Aerosols; Foams}
- A61K 8/34: Alcohols
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof}
- A61K 8/37: Esters of carboxylic acids
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups
- A61K 8/41: Amines
- A61K 8/42: Amides
- A61K 8/8147: {Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers}
- A61K 8/86: Polyethers
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)}
- A61K 9/122: {Foams; Dry foams (edible foams A61K9/0056)}
- A61K 9/14: Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)}
- A61K 31/16: Amides, e.g. hydroxamic acids
- A61K 47/08: containing oxygen, {e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61P 17/14: for baldness or alopecia
- A61Q 7/00: Preparations for affecting hair growth
- A61K 2800/592: Mixtures of compounds complementing their respective functions
- A61K 2800/74: Biological properties of particular ingredients
- A61K 2800/87: Application Devices; Containers; Packaging
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

## Claims

### Claim 1

A method of stimulating hair growth, the method comprising topically administering to a region of skin of a patient in need thereof a composition comprising:
0.01% to 5% w/w bimatoprost in free form or a pharmaceutically acceptable salt thereof; and, a penetration enhancer comprising a combination of
a first penetration enhancer group comprising ethanol, propylene glycol, and diethylene glycol monoethyl ether, and
a second penetration enhancer group comprising an effective amount of at least two compounds selected from the group consisting of glycerol monooleate, oleic acid, and benzyl alcohol.

### Claim 2 (depends on 1)

The method of claim 1, wherein the region of skin is a scalp of the patient.

### Claim 3 (depends on 1)

The method of claim 1, wherein the region of skin is a face of the patient.

### Claim 4 (depends on 1)

The method of claim 1, wherein the region of skin is under or near one or more eyebrows of the patient.

### Claim 5 (depends on 1)

The method of claim 1, wherein the region of skin is under or near one or more eyelids of the patient.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition is administered to the skin once daily.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition is administered to the skin twice daily.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition comprises about 0.03% w/w to about 5% w/w bimatoprost.

### Claim 9 (depends on 8)

The method of claim 8, wherein the composition comprises 1% w/w bimatoprost.

### Claim 10 (depends on 1)

The method of claim 1, wherein administration of the composition is effective for the treatment of at least one of the conditions selected from the group consisting of alopecia areata, telogen effluvium, anagen effluvium, cicatricial alopecia, scarring alopecia; hair shaft abnormalities, trichorrexis nodosa, loose anagen syndrome, trichotillomania, traction alopecia, infectious hair disorders, tiniea capitis, sebohorreic dermatitis, follicullitus of the scalp, and androgenetic alopecia.

### Claim 11 (depends on 1)

The method of claim 1, wherein the method stimulates the conversion of vellus hair to terminal hair.

### Claim 12 (depends on 1)

The method of claim 1, wherein the method increases the rate of growth of terminal hair.