# US 9,750,739 B2 · Orvepitant for chronic cough therapy

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- Number: US 9,750,739 B2
- Document ID: US9750739B2
- Status: Granted
- Kind: B2
- Application number: 15/390,770
- Filed: 2016-12-27
- Published: 2017-07-13
- Granted: 2017-09-05
- Earliest claimed: 2016-01-08
- Assignees: NeRRe Therapeutics Limited
- Applicants: NeRRe Therapeutics Limited
- Inventors: Mike Trower
- Web page: https://patentgrep.com/patent/US9750739B2

## CPC

- A61K 31/4985: Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 31/194: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 11/14: Antitussive agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to the new use of the compound 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide (orvepitant) or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing it for the treatment of chronic cough, including chronic refractory cough and to combinations for such a use.

## Claims

### Claim 1

A method of treatment of chronic cough, comprising administering to a human in need thereof a therapeutically effective amount of 2-(R)-(4-Fluoro-2-methyl-phenyl)-4-(S)-((8aS)-6-oxo-hexahydro-pyrrolo[1,2-a]-pyrazin-2-yl)-piperidine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methylamide (orvepitant) or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is chronic refractory cough.

### Claim 3 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is due to or associated with sarcoidosis, emphysema or idiopathic pulmonary fibrosis (IPF).

### Claim 4 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is due to or associated with asthma, chronic bronchitis, chronic postnasal drip, eosinophilic bronchitis or chronic obstructive pulmonary disease (COPD).

### Claim 5 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is due to or associated with chronic infections.

### Claim 6 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is due or associated with lung tumours, said lung tumours being bronchogenic carcinoma, alveolar cell carcinoma, benign airway tumours or mediastinal tumours.

### Claim 7 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is due to or associated with a cardiovascular disease, said cardiovascular disease being left ventricular failure, pulmonary infarction or aortic aneurysm.

### Claim 8 (depends on 1)

A method of treatment according to claim 1, wherein the chronic cough is due to or associated with reflux oesophagitis, recurrent aspiration, endobronchial sutures, postnasal drip syndrome or rhinosinusitis.

### Claim 9 (depends on 1)

A method of treatment according to claim 1, wherein the pharmaceutically acceptable salt of the compound is maleate.

### Claim 10 (depends on 1)

A method of treatment according to claim 1, wherein the compound is orvepitant maleate Form 1.

### Claim 11 (depends on 1)

A method of treatment according to claim 1 wherein the chronic cough is due to or associated with bronchiectasis, tuberculosis or cystic fibrosis.