# US 9,750,714 B2 · Pharmaceutical use of 3, 4-bis-benzylsulfonylbutyronitrile

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- Number: US 9,750,714 B2
- Document ID: US9750714B2
- Status: Granted
- Kind: B2
- Application number: 15/262,176
- Filed: 2016-09-12
- Published: 2017-03-09
- Granted: 2017-09-05
- Earliest claimed: 2013-09-26
- Assignees: Olatec Therapeutics LLC
- Applicants: Olatec Therapeutics LLC
- Inventors: Joseph P. St. Laurent; Gerald S. Jones; David M. Bresse; Scott A. Goodrich
- Web page: https://patentgrep.com/patent/US9750714B2

## CPC

- A61K 31/277: having a ring, e.g. verapamil
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- C07C 315/02: by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
- C07C 317/28: with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C 317/44: having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C 319/12: by reactions not involving the formation of mercapto groups
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

The present invention is directed to a method of treating inflammation or pain. The present invention is also directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method comprises administering to the subject 3, 4-bis-benzylsulfonylbutyronitrile in an amount effective to reduce or eliminate the symptoms of the disease or disorder. Topical administration and oral administration are preferred route of administration.

## Claims

### Claim 1

A method of treating inflammation or pain, comprising the steps of:
administering to a subject suffering from inflammation or pain 3, 4-bis-benzylsulfonylbutyronitrile or a pharmaceutically acceptable salt thereof, in an amount effective to treat inflammation or pain.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said method reduces or alleviates the symptoms of localized manifestations of inflammation characterized by acute or chronic swelling, pain, or redness.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said compound is administered by topical administration or oral administration.

### Claim 4 (depends on 1)

The method according to claim 1, wherein said pain is nociceptive pain.

### Claim 5 (depends on 1)

The method according to claim 1, wherein said inflammation and/or pain is associated with a skeletal or muscular disease or condition selected from the group consisting of: musculoskeletal sprains, musculoskeletal strains, tendonopathy, peripheral radiculopathy, osteoarthritis, degenerative joint disease, juvenile arthritis, gout, ankylosing spondylitis, psoriatic arthritis, system lupus erythematosus, costochondritis, tendonitis, bursitis, temporomandibular joint syndrome, and fibromyalgia.

### Claim 6 (depends on 1)

The method according to claim 1, wherein said inflammation and/or pain is associated with joints, ligaments, tendons, bone, muscles, or fascia.

### Claim 7 (depends on 1)

The method according to claim 1, wherein said inflammation and/or pain is associated with an inflammatory skin disease or disorder of dermatitis or psoriasis.

### Claim 8

A method of treating an inflammatory skin disease or disorder, comprising the steps of:
administering 3, 4-bis-benzylsulfonylbutyronitrile or a pharmaceutically acceptable salt thereof, to a subject in need thereof, in an amount effective to reduce or eliminate the symptoms of the inflammatory skin disease or disorder,
wherein the inflammatory skin disease or disorder is dermatitis, psoriasis, acne, or rosacea.

### Claim 9 (depends on 8)

The method according to claim 8, wherein said method treats atopic dermatitis and alleviates one or more symptoms selected from the group consisting of erythema, induration, lichenification, scaling, and oozing and crusting.

### Claim 10 (depends on 8)

The method according to claim 8, wherein said method treats contact dermatitis and alleviates one or more symptoms selected from the group consisting of erythema, edema, lichenification, scaling, fissuring, and micro or macrovesiculation.

### Claim 11 (depends on 8)

The method according to claim 8, wherein said method treats psoriasis and alleviates erythema, scaling, and/or thickness of the psoriasis lesions.

### Claim 12 (depends on 8)

The method according to claim 8, wherein said method treats acne and alleviates one or more lesions selected from the groups consisting of closed comedones, papules, pustules, nodules, and cysts, or said method treats rosacea and alleviates one or more symptoms selected from the group consisting of erythema, telangiectasia, red domed papules and pustules, red gritty eyes, and burning and stinging sensations.