# US 9,750,695 B2 · Cross-linked polymer particles

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- Number: US 9,750,695 B2
- Document ID: US9750695B2
- Status: Granted
- Kind: B2
- Application number: 14/673,060
- Filed: 2015-03-30
- Published: 2015-07-23
- Granted: 2017-09-05
- Earliest claimed: 2006-11-03
- Assignees: Boston Scientific Scimed, Inc.
- Applicants: Boston Scientific Scimed, Inc.
- Inventors: Robert E. Richard
- Web page: https://patentgrep.com/patent/US9750695B2

## CPC

- A61K 9/14: Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/0034: {Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants}
- A61K 9/167: {with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface (with further drug-free outer coating A61K9/5073)}
- A61K 9/1676: {having a drug-free core with discrete complete coating layer containing drug (adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921)}
- A61K 9/5031: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)}
- A61K 9/5036: {Polysaccharides, e.g. gums, alginate; Cyclodextrin}
- A61K 9/5057: {Gelatin}
- A61K 9/5073: {having two or more different coatings optionally including drug-containing subcoatings}
- A61K 9/5078: {with drug-free core}
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- B32B 5/16: characterised by features of a layer formed of particles, e.g. chips, powder {or granules (layer formed of natural mineral particles B32B19/00; layer being formed of wood fibres, chips or particles B32B21/02)}
- C08J 3/24: Crosslinking, e.g. vulcanising, of macromolecules (mechanical aspects B29C35/00; crosslinking agents C08K)
- C08J 9/365: {Coating}
- A61F 6/14: intra-uterine type
- A61K 31/4192: 1,2,3-Triazoles
- C08J 2201/024: Preparation or use of a blowing agent concentrate, i.e. masterbatch in a foamable composition
- C08J 2329/04: Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
- Y10T 428/2982: Particulate matter [e.g., sphere, flake, etc.]
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- B32B: LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed.

## Claims

### Claim 1

A method of treating a patient, comprising:
placing a particle within a tissue of a patient, the particle comprising a polymer backbone bonded to a chemical species via a 1,2,3-triazole group, wherein the particle has a maximum dimension of at most 5,000 microns, and wherein the polymer backbone comprises polyvinyl alcohol.

### Claim 2 (depends on 1)

The method of claim 1, wherein the particle occludes a uterine artery leading to a fibroid.

### Claim 3 (depends on 1)

The method of claim 1, wherein the chemical species further comprises a second polymer backbone selected from the group consisting of polyvinyl alcohol and polyglycolic acid.

### Claim 4

A method of treating a patient, comprising:
placing a particle within a tissue of a patient, the particle comprising:
a first polymer backbone;
a second polymer backbone; and
a 1,2,3-triazole group,
wherein the 1,2,3-triazole group is covalently bonded to the first and second polymer backbones to cross-link the first and second polymer backbones, and the particle has a maximum dimension of at most about 5,000 microns and the first and second polymer backbones comprises polyvinyl alcohol.

### Claim 5 (depends on 4)

The method of claim 4, wherein the particle occludes a uterine artery leading to a fibroid.

### Claim 6

A method of treating a patient, comprising:
placing a carrier fluid within a tissue of a patient, the carrier fluid comprising a plurality of particles, wherein at least some of the plurality of particles have a maximum dimension of at most about 5,000 microns and comprise a material comprising a first polymer backbone cross-linked to a second polymer backbone via a 1,2,3-triazole group and the first and second polymer backbones comprise polyvinyl alcohol.

### Claim 7 (depends on 6)

The method of claim 6, wherein the particle occludes a uterine artery leading to a fibroid.