# US 9,750,691 B2 · Pheromone compositions and their use to modify behavior in different vertebrate species > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,691 B2 - Document ID: US9750691B2 - Status: Granted - Kind: B2 - Application number: 13/623,319 - Filed: 2012-09-20 - Published: 2013-03-21 - Granted: 2017-09-05 - Earliest claimed: 2011-09-20 - Assignees: Sergeant's Pet Care Products, Inc. - Applicants: Sergeant's Pet Care Products, Inc. - Inventors: John McGlone; Larry Nouvel - Web page: https://patentgrep.com/patent/US9750691B2 ## CPC - A61K 9/124: {characterised by the propellant} - A61K 9/008: {comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]} - A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)} - A61K 31/565: not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol - A61K 31/568: substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61P 25/00: Drugs for disorders of the nervous system - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A composition comprising an INTEROMONE® is described for the modification of undesirable or harmful stress-related behaviors or other behaviors or physiology in a variety of vertebrate species, as well as methods of using the compositions in vertebrates from a species different than the species in which the INTEROMONE® is a naturally occurring pheromone. ## Claims ### Claim 1 A method of modifying behavior in an animal, the method comprising: administering a composition to the animal for a period of time, the composition comprising between about 0.001% and about 1% (w/w) 2-methylbut-2-enal and between about 0.5% and 99.99% (w/w) of at least one solvent, wherein the animal is a dog or a cat, and wherein anxiety, stress, and aggressiveness in the animal is reduced. ### Claim 2 (depends on 1) The method of claim 1, wherein the method of administration is inhalation. ### Claim 3 (depends on 1) The method of claim 1, wherein the composition is formulated as a spray, a diffuser, or a slow release matrix. ### Claim 4 (depends on 3) The method of claim 3, wherein administering the spray composition comprises spraying the animal or spraying the animal's environment with the composition. ### Claim 5 (depends on 1) The method of claim 1, wherein the period of time is at least one second. ### Claim 6 (depends on 1) The method of claim 1, wherein the period of time is at least one week. ### Claim 7 (depends on 1) The method of claim 1, wherein the period of time is at least one month. ### Claim 8 (depends on 1) The method of claim 1, wherein the composition comprises at least one additional pheromone or pheromone composition. ### Claim 9 A method of modifying behavior in an animal, the method comprising: administering an effective amount of a spray composition to the animal for a period of time, the spray composition comprising about 0.01% (w/w) 2-methylbut-2-enal, about 10% (w/w) isopropyl alcohol, and about 89.49% (w/w) water, wherein the animal is a dog or a cat, and wherein anxiety, stress, and aggressiveness in the animal is reduced. ### Claim 10 A method of modifying behavior in an animal, the method comprising: administering an effective amount of a diffuser composition to the animal for a period of time, the diffuser composition comprising about 0.02% (w/w) 2-methylbut-2-enal, about 15% (w/w) isopropyl palmitate, and about 84.48% (w/w) silicone fluid, wherein the animal is a dog or a cat, and wherein anxiety, stress, and aggressiveness in the animal is reduced. ### Claim 11 A method of modifying behavior in an animal, the method comprising: administering an effective amount of a slow release matrix composition to the animal for a period of time, the slow release matrix composition comprising about 0.02% (w/w) 2-methylbut-2-enal, and about 99.780% (w/w) copolymer, wherein the animal is a dog or a cat, and wherein anxiety, stress, and aggressiveness in the animal is reduced. ### Claim 12 (depends on 1) The method of claim 1, wherein the animal is a dog. ### Claim 13 A method of calming an animal, the method comprising: administering a composition to the animal for a period of time, the composition comprising between about 0.001% and about 1% (w/w) of 2-methylbut-2-enal and between about 0.5% and 99.99% (w/w) of at least one carrier solvent, wherein the animal is a dog or a cat.