# US 9,750,677 B2 · Use of metal complexes which are mimetics of SOD as food agents and as cosmetics

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- Number: US 9,750,677 B2
- Document ID: US9750677B2
- Status: Granted
- Kind: B2
- Application number: 15/121,030
- Filed: 2015-02-24
- Published: 2017-01-12
- Granted: 2017-09-05
- Earliest claimed: 2014-02-24
- Applicants: Universitat de València
- Inventors: Enrique García-España Monsonís; María Paz Clares García; Salvador Blasco Llopis; Concepción Soriano Soto; Jorge González García; Begoña Verdejo Viu
- Web page: https://patentgrep.com/patent/US9750677B2

## CPC

- A61K 8/494: {with more than one nitrogen as the only hetero atom}
- A23B 2/771: Organic compounds containing hetero rings
- A23B 2/788: Inorganic compounds
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 5/00: Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/165: Complexes or chelates
- A61K 8/19: containing inorganic ingredients
- A61Q 19/00: Preparations for care of the skin
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2800/10: General cosmetic use
- A61K 2800/522: Antioxidants; Radical scavengers
- A61K 2800/58: Metal complex; Coordination compounds
- C07D 471/08: Bridged systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

This invention relates to the use of the metal complexes which are mimetics of the superoxide dismutase (SOD) enzyme produced from macrocyclic polyazapyridinophane compounds of formula (1) as food agents and also as cosmetics.

## Claims

### Claim 1

A cosmetic formulation comprising a metal complex mimetic of superoxide dismutase of Formula 1 with at least one metal ion

### Claim 2

A food agent comprising a metal complex mimetic of superoxide dismutase of Formula 1 with at least one metal ion

### Claim 3 (depends on 1)

The cosmetic formulation of claim 1, wherein the metal ion comprises Cu(II), Fe(II) or Mn(II).

### Claim 4 (depends on 3)

The cosmetic formulation of claim 3, wherein the ion is Mn(II).

### Claim 5 (depends on 2)

The food agent of claim 2, wherein the food agent is a food additive, dietary supplement, functional food or functional drink.

### Claim 6

A personal hygiene product comprising a metal complex mimetic of superoxide dismutase of Formula 1 with at least one metal ion

### Claim 7 (depends on 1)

The cosmetic formulation of claim 1, wherein said formulation is formulated as a cream, paste, milk, gel, lotion, ointment, suspension, dispersion, powder, shampoo, foam, spray or solid bar.

### Claim 8 (depends on 2)

The food agent of claim 2, wherein the metal ion comprises Cu(II), Fe(II) or Mn(II).

### Claim 9 (depends on 8)

The food agent of claim 8, wherein the ion is Mn(II).

### Claim 10 (depends on 6)

The personal hygiene product of claim 6, wherein the cosmetic formulation is formulated as a cream, paste, milk, gel, lotion, ointment, suspension, dispersion, powder, shampoo, foam, spray or solid bar.