# US 9,750,606 B2 · Systems and methods for heart valve therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,606 B2 - Document ID: US9750606B2 - Status: Granted - Kind: B2 - Application number: 14/673,055 - Filed: 2015-03-30 - Published: 2016-04-28 - Granted: 2017-09-05 - Earliest claimed: 2014-10-23 - Assignees: Caisson Interventional, LLC - Applicants: Caisson Interventional, LLC - Inventors: Kavitha Ganesan; Ramji Venkatasubramanian; Andrew T. Forsberg; Cyril J. Schweich, Jr.; Todd J. Mortier; Erik O. Martz; Douglas J. Krone - Web page: https://patentgrep.com/patent/US9750606B2 ## CPC - A61F 2/2427: {Devices for manipulating or deploying heart valves during implantation} - A61F 2/2412: {with soft flexible valve members, e.g. tissue valves shaped like natural valves} - A61F 2/2418: {Scaffolds therefor, e.g. support stents} - A61F 2/2436: {Deployment by retracting a sheath} - A61F 2/2439: {Expansion controlled by filaments} - A61F 2250/006: modular - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract Prosthetic mitral valves described herein can be deployed using a transcatheter mitral valve delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native mitral valve. This document describes prosthetic heart valve designs that interface with native mitral valve structures to create a fluid seal, thereby minimizing mitral regurgitation and paravalvular leaks. This document also describes prosthetic heart valve designs and techniques to manage blood flow through the left ventricular outflow tract. In addition, this document describes prosthetic heart valve designs and techniques that reduce the risk of interference between the prosthetic valves and chordae tendineae. ## Claims ### Claim 1 A mitral valve replacement system for a heart, comprising: an expandable anchor assembly configured to implant at a native mitral valve, the expandable anchor assembly including a first expandable frame that is adjustable from a delivery condition to an expanded condition; a first delivery sheath device having a distal end insertable into a left atrium and being configured to express the anchor assembly out from the distal end such that the anchor assembly expands within the left atrium to the expanded condition; a pusher instrument releasably attachable to the first expandable frame and being configured to longitudinally advance the anchor assembly within the left atrium towards an annulus of the native mitral valve while the anchor assembly is in the expanded condition; and an artificial valve assembly comprising a second expandable frame that is slidably engaged with an exterior of the pusher instrument and adjustable from a compressed condition to a deployed condition to selectively engage with the anchor assembly while the anchor assembly is in the expanded condition. ### Claim 2 (depends on 1) The system of claim 1, wherein the anchor assembly comprises a plurality of sub-annular projections configured to engage tissue proximate to the annulus of the native mitral valve while preserving natural function of anterior and posterior leaflets of the native mitral valve. ### Claim 3 (depends on 1) The system of claim 1, further comprising a second delivery sheath device having a distal end insertable into a left atrium and being configured to express the artificial valve assembly out from the distal end such that the artificial valve assembly at least expands within the left atrium. ### Claim 4 (depends on 1) The system of claim 1, wherein the artificial valve assembly comprises a guide structure to slidably engage with an exterior of the pusher instrument while the pusher instrument is releasably attached to the first expandable frame. ### Claim 5 (depends on 1) The system of claim 1, wherein the second expandable frame of the artificial valve assembly is separately expandable from the anchor assembly and further comprises: a generally D-shaped outer peripheral region, and a circular valve orifice located radially inward from the generally D-shaped outer peripheral region and carrying valve leaflets that define a circular perimeter at the circular valve orifice. ### Claim 6 (depends on 1) The system of claim 1, wherein the artificial valve assembly is releasably coupled to a control catheter that defines a lumen, and wherein the artificial valve assembly is slidably engaged with an exterior of the pusher instrument by slidably disposing the pusher instrument within the lumen of the control catheter. ### Claim 7 (depends on 1) The system of claim 1, further comprising a guidewire slidably disposable within the pusher instrument. ### Claim 8 A mitral valve replacement system for a heart, comprising: an expandable anchor assembly configured to implant at a native mitral valve, the expandable anchor assembly including a first expandable frame that is adjustable from a delivery condition to an expanded condition; a first delivery sheath device having a distal end insertable into a left atrium and being configured to express the anchor assembly out from the distal end such that the anchor assembly expands within the left atrium to the expanded condition; a pusher instrument releasably attachable to the first expandable frame and being configured to longitudinally advance the anchor assembly within the left atrium towards an annulus of the native mitral valve while the anchor assembly is in the expanded condition; an anchor assembly control wire slidably disposable within the first delivery sheath device, wherein the anchor assembly control wire is coupled with the anchor assembly; and an artificial valve assembly comprising a second expandable frame that is adjustable from a compressed condition to a deployed condition to selectively engage with the anchor assembly while the anchor assembly is in the expanded condition. ### Claim 9 A mitral valve replacement system for a heart, comprising: an expandable anchor assembly configured to implant at a native mitral valve, the expandable anchor assembly including a first expandable frame that is adjustable from a delivery condition to an expanded condition; a first delivery sheath device having a distal end insertable into a left atrium and being configured to express the anchor assembly out from the distal end such that the anchor assembly expands within the left atrium to the expanded condition; a pusher instrument releasably attachable to the first expandable frame and being configured to longitudinally advance the anchor assembly within the left atrium towards an annulus of the native mitral valve while the anchor assembly is in the expanded condition; a secondary deflectable catheter slidably disposed between the first delivery sheath device and the pusher instrument; and an artificial valve assembly comprising a second expandable frame that is adjustable from a compressed condition to a deployed condition to selectively engage with the anchor assembly while the anchor assembly is in the expanded condition. ### Claim 10 (depends on 9) The system of claim 9, wherein a distal end portion of the secondary deflectable catheter is controllably laterally deflectable. ### Claim 11 An implantable medical device delivery system comprising: a first deflectable catheter defining a first lumen therethrough, wherein a distal end portion of the first deflectable catheter is controllably laterally deflectable; a first device delivery sheath slidably disposable within the first lumen, the first device delivery sheath defining a second lumen therethrough; a first device control sheath slidably disposable within the second lumen, the first device control sheath defining a third lumen therethrough and one or more first device control wire lumens; a second deflectable catheter slidably disposable within the third lumen, the second deflectable catheter defining a fourth lumen therethrough, wherein a distal end portion of the second deflectable catheter is controllably laterally deflectable; and a device pusher catheter slidably disposable within the fourth lumen, the device pusher catheter defining a fifth lumen therethrough, a distal end portion of the device pusher catheter configured to releasably couple with a first implantable medical device. ### Claim 12 (depends on 11) The delivery system of claim 11, further comprising a guidewire slidably disposable within the fourth lumen. ### Claim 13 (depends on 11) The delivery system of claim 11, further comprising a second device delivery sheath slidably disposable within the first lumen, the second device delivery sheath defining a sixth lumen therethrough. ### Claim 14 (depends on 13) The delivery system of claim 13, further comprising a second device control sheath slidably disposable within the sixth lumen, the second device control sheath defining a seventh lumen therethrough and one or more second device control wire lumens, the distal pusher catheter being slidably disposable within the seventh lumen. ### Claim 15 (depends on 14) The delivery system of claim 14, further comprising a first device control wire slidably disposable within the one or more first device control wire lumens and a second device control wire slidably disposable within the one or more second device control wire lumens.