# US 9,750,602 B2 · Methods of predicting the post-operative position of an IOL and uses of such methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,602 B2 - Document ID: US9750602B2 - Status: Granted - Kind: B2 - Application number: 14/003,151 - Filed: 2012-03-08 - Published: 2013-12-26 - Granted: 2017-09-05 - Earliest claimed: 2011-03-09 - Assignees: IOL Innovations ApS - Applicants: Thomas Olsen - Inventors: Thomas Olsen - Web page: https://patentgrep.com/patent/US9750602B2 ## CPC - A61F 2/16: Intraocular lenses - A61B 3/0025: {characterised by electronic signal processing, e.g. eye models} - A61B 3/1005: {for measuring distances inside the eye, e.g. thickness of the cornea (A61B3/11 takes precedence)} - A61B 5/0082: {adapted for particular medical purposes} - A61B 5/1072: {measuring distances on the body, e.g. measuring length, height or thickness (A61B5/1076 takes precedence)} - A61B 8/08: Clinical applications (A61B8/02, A61B8/04, A61B8/06 take precedence) - A61B 8/0858: {involving measuring tissue layers, e.g. skin, interfaces} - A61B 8/10: Eye inspection - A61B 34/10: Computer-aided planning, simulation or modelling of surgical operations - A61F 2240/002: Designing or making customized prostheses - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract The invention relates to the field of ophthalmic systems and procedures. In particular, the invention relates to the determination of the post-operative position of an intraocular lens (termed “IOL”) in an eye of a patient undergoing lens replacement surgery, which involves determining the position of the existing crystalline lens in the pre-operative eye of the patient and using that information and a single numerical constant to predict the post-operative intraocular lens position. Related methods, and computer programs for performing the methods of the invention, are also disclosed. ## Claims ### Claim 1 A method for implanting a replacement intraocular lens into an eye of a patient, the method comprising the steps of: (a2) predicting the post-operative position of the intraocular lens in the eye of the patient by (i) determining the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) determining the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii) predicting the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b2) optionally, removing the crystalline lens from the pre-operative eye of the patient; (c2) providing an intraocular lens; and (d2) implanting the intraocular lens into the eye of the patient. ### Claim 2 (depends on 1) The method according to claim 1 wherein the intraocular lens provided in step (c2) is selected using a method comprising the steps of: (a) predicting the post-operative position of a replacement intraocular lens in the eye of the patient using a method comprising the steps of: (i) determining the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) determining the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii) predicting the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b) predicting the optical properties of the post-operative eye of the patient in which an intraocular lens of known power and geometry is positioned as predicted in step (a); and (c) selecting an intraocular lens having a power and geometry required to provide the desired optical property in the post-operative eye of the patient. ### Claim 3 (depends on 1) The method according to claim 1 wherein the intraocular lens provided in step (c2) is designed, and optionally manufactured, using a method comprising the steps of: (a1) predicting the post-operative position of an intraocular lens in the eye of the patient using a method comprising the steps of: (i) determining the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) determining the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii) predicting the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b1) predicting the optical properties of the post-operative eye of the patient in which an intraocular lens of known power and geometry is positioned as predicted in step (a); (c1) designing an intraocular lens having a power and geometry required to provide the desired optical property in the post-operative eye of the patient; and (d1) optionally, manufacturing the intraocular lens designed in step (c1). ### Claim 4 (depends on 1) The method according to claim 1 wherein implanting the intraocular lens into the eye of the patient in step (d2) comprises implanting the intraocular lens into the capsular bag in the eye of the patient. ### Claim 5 A method for treating and/or preventing and/or reducing a disease or disorder in the eye of a patient, the method comprising the steps of: (a3) predicting the post-operative position of the intraocular lens in the eye of the patient by (i) determining the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) determining the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii) predicting the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b3) optionally, removing the crystalline lens from the pre-operative eye of the patient; (c3) providing an intraocular lens; and (d3) implanting the intraocular lens into the eye of the patient. ### Claim 6 (depends on 5) The method according to claim 5 wherein the intraocular lens provided in step (c3) is selected using a method comprising the steps of: (a) predicting the post-operative position of a replacement intraocular lens in the eye of the patient using a method comprising the steps of: (i) determining the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) determining the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii) predicting the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b) predicting the optical properties of the post-operative eye of the patient in which an intraocular lens of known power and geometry is positioned as predicted in step (a); and (c) selecting an intraocular lens having a power and geometry required to provide the desired optical property in the post-operative eye of the patient. ### Claim 7 (depends on 5) The method according to claim 5 wherein the intraocular lens provided in step (c3) is designed, and optionally manufactured, using a method comprising the steps of: (a1) predicting the post-operative position of an intraocular lens in the eye of the patient using a method comprising the steps of: (i) determining the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) determining the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii)predicting the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b1) predicting the optical properties of the post-operative eye of the patient in which an intraocular lens of known power and geometry is positioned as predicted in step (a); (c1) designing an intraocular lens having a power and geometry required to provide the desired optical property in the post-operative eye of the patient; and (d1) optionally, manufacturing the intraocular lens designed in step (c1). ### Claim 8 (depends on 5) The method according to claim 5 wherein implanting the intraocular lens into the eye of the patient in step (d3) comprises implanting the intraocular lens into the capsular bag in the eye of the patient. ### Claim 9 (depends on 5) The method according to claim 5 wherein the disease or disorder in the eye of the patient is selected from the group consisting of: Myopia; Hyperopia; Presbyopia; Astigmatism; Refractive errors; Cataract; Opacities; and Brunescence. ### Claim 10 A method for designing a replacement intraocular lens required to provide a desired optical property in the post-operative eye of a patient, the method comprising the steps of: (a1) predicting the post-operative position of an intraocular lens in the eye of the patient using a method comprising the steps of: (i) measuring the position of the existing crystalline lens in the pre-operative eye of the patient; (ii) measuring the thickness of the crystalline lens in the pre-operative eye of the patient; and (iii) calculating the post-operative position of the intraocular lens relative to the position of the crystalline lens in the pre-operative eye of the patient, as a proportion of the thickness of the crystalline lens in the pre-operative eye of the patient, wherein the proportion is defined by a single numerical constant (C) which is determined by the intraocular lens type; (b1) calculating the optical properties of the post-operative eye of the patient in which an intraocular lens of known power and geometry is positioned as predicted in step (a); (c1) designing an intraocular lens having a power and geometry required to provide the desired optical property in the post-operative eye of the patient; and (d1) manufacturing the intraocular lens designed in step (c1).