# US 9,750,601 B2 · Method and apparatus for endothelial keratoplasty

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- Number: US 9,750,601 B2
- Document ID: US9750601B2
- Status: Granted
- Kind: B2
- Application number: 14/430,978
- Filed: 2013-09-12
- Published: 2015-08-27
- Granted: 2017-09-05
- Earliest claimed: 2012-09-27
- Assignees: E.K.—D.D.S. Ltd.
- Applicants: E.K.-D.D.S. Ltd.
- Inventors: Natan Galperin
- Web page: https://patentgrep.com/patent/US9750601B2

## CPC

- A61F 2/148: {Implantation instruments specially adapted therefor}
- A61B 18/08: by means of electrically-heated probes
- A61F 2/142: {Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue}
- A61F 9/0081: {Transplantation}
- A61F 9/00831: {Transplantation}
- A61F 2009/00872: {Cornea}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A tool for endothelial implantation comprising a base frame on a stem and a covering frame such that the base frame is insertable between a stroma and a Descemet's membrane and the covering frame is positionable over the base frame to lockingly engage the base frame trapping a section of Descemet's membrane between the base frame and the cover frame for surgical separation of the section by cutting therearound.

## Claims

### Claim 1

A tool for endothelial manipulation and implantation in a recipient eye, the recipient eye having a cornea, a stoma and an anterior chamber, the tool comprising:
a) a framework on a stem configured to be insertable through an incision in the recipient eye's cornea between the recipient eye's stoma and the recipient eye's anterior chamber, said framework being positionable to hold a section of Descemet's membrane in a manner suitable for surgical manipulation of said section of Descemet's membrane; and,
b) a heating element in said framework, said heating element having connecting wires to couple said heating element to a power supply via a switch, said heating element being configured so that activation of the switch burns the perimeter of said section of Descemet's membrane within said framework thereby releasing said section of Descemet's membrane from said framework.

### Claim 2 (depends on 1)

The tool of claim 1, wherein said framework is circular.

### Claim 3 (depends on 1)

The tool of claim 1, wherein said framework is coupled by the stem to a lid, and said lid being sealingly attachable to a container of solution, and configured so that a section of Descemet's membrane from a donor is sealingly preservable in said solution for a time period.

### Claim 4 (depends on 1)

The tool of claim 1, wherein said stem provides fluid communication between at least one outlet in said framework and an injector having a reservoir of gas so that an injection of gas from said injector releases gas below said section of Descemet's membrane to float said section of Descemet's membrane into position against the recipient eye's stoma.

### Claim 5

A method of surgically replacing a section of Descemet's membrane in a recipient eye, the recipient eye having a cornea, a stoma and an anterior chamber said method comprising the steps of:
a) obtaining a section of Descemet's membrane from a donor eye, and placing said section of Descemet's membrane on a framework;
b) making an incision in a recipient eye's cornea and removing a section of damaged Descemet's membrane from the recipient eye via said incision;
c) inserting said framework containing said section of Descemet's membrane through said incision into said recipient eye to a position between the recipient eye's stoma and the recipient eye's anterior chamber;
d) applying electrical current to heat the perimeter of said section of Descemet's membrane, thereby detaching said section of Descemet's membrane from said framework, thereby placing said section of Descemet's membrane into an appropriate position in said recipient eye; and
e) releasing gas below said section of Descemet's membrane to float said section of Descemet's membrane into position against the recipient eye's stoma.