# US 9,750,575 B2 · Evaluation of patency using photo-plethysmography on endoscope images > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,575 B2 - Document ID: US9750575B2 - Status: Granted - Kind: B2 - Application number: 14/407,972 - Filed: 2013-06-20 - Published: 2015-06-18 - Granted: 2017-09-05 - Earliest claimed: 2012-06-28 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Haytham Elhawary; Aleksandra Popovic; Willem Verkruijsse - Web page: https://patentgrep.com/patent/US9750575B2 ## CPC - A61B 34/30: Surgical robots - A61B 1/0005: {combining images e.g. side-by-side, superimposed or tiled} - A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)} - A61B 5/0261: {using optical means, e.g. infrared light} - A61B 5/0295: using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography - A61B 5/061: {Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body (A61B1/00158 takes precedence)} - A61B 5/1459: invasive, e.g. introduced into the body by a catheter - A61B 5/4851: {Prosthesis assessment or monitoring} - A61B 5/7285: {for synchronizing or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal} - A61B 2034/301: {for introducing or steering flexible instruments inserted into the body, e.g. catheters or endoscopes} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A system for evaluating patency includes a light sensor (128) positionable relative to a blood vessel to receive light from the blood vessel and convert the light into an image signal. A photo-plethysmography (PPG) interpretation module (115) is configured to receive the image signal and output pixel values in an image representing PPG information. An image generation module (148) is coupled to the PPG interpretation module to receive the pixel values and generate a PPG map to be output to a display for analysis. ## Claims ### Claim 1 A system for evaluating patency, comprising: a light source configured to generate light for illuminating a blood vessel; a light sensor positioned on an endoscope and positionable relative to the blood vessel, the light sensor being configured to receive light from the blood vessel responsive to the generated light and convert the light into an image signal; a photo-plethysmography (PPG) interpretation module configured to receive the image signal and output pixel values in an image representing PPG information; and an image generation module coupled to the PPG interpretation module and configured to receive the pixel values and generate a PPG map to be output to a display for analysis. ### Claim 2 (depends on 1) The system as recited in claim 1, wherein the light sensor includes a camera. ### Claim 3 (depends on 1) The system as recited in claim 1, further comprising a robot which includes the light sensor mounted thereon, the robot being configured to position the light sensor relative to the blood vessel. ### Claim 4 (depends on 1) The system as recited in claim 1, wherein the light sensor is configured to be positioned at a position relative to the blood vessel at a first time to obtain a first PPG map and is further configured to be positioned in the same position at a second time to obtain a second PPG map, enabling comparison of the first and second PPG map to determine PPG changes in the blood vessel. ### Claim 5 (depends on 4) The system as recited in claim 4, further comprising a robot which includes the light sensor mounted thereon, the robot being configured to enable repeatable positioning of the light sensor at different times. ### Claim 6 (depends on 1) The system as recited in claim 1, wherein the image generation module is further configured to generate a subtraction image of the first and second PPG maps from the first and second times. ### Claim 7 (depends on 1) The system as recited in claim 1, wherein the image generation module is further configured to overlay the subtraction image on an image from the image signal provided by the light sensor. ### Claim 8 (depends on 1) The system as recited in claim 1, wherein the image generation module is further configured to overlay the PPG map on an image from the image signal provided by the light sensor. ### Claim 9 (depends on 1) The system as recited in claim 1, wherein the image generation module is further configured to overlay the PPG map on an X-ray image. ### Claim 10 (depends on 1) The system as recited in claim 1, wherein the blood vessel includes a bypass graft and the PPG map indicates blood flow through the graft at different times. ### Claim 11 (depends on 1) The system as recited in claim 1, wherein the light source is positioned on the endoscope. ### Claim 12 A method for evaluating patency, comprising: positioning a light sensor relative to a blood vessel using an endoscope to receive light from the blood vessel illuminated by a radiation source; converting the light received from the blood vessel into an image signal; interpreting the image signal to determine a photo-plethysmography (PPG) signal and outputting pixel values in an image representing PPG information; generating a PPG map to be output to a display for analysis from the pixel values; and analyzing at least one PPG map to determine patency of the blood vessel. ### Claim 13 (depends on 12) The method as recited in claim 12, wherein the light sensor includes a camera mounted on endoscope. ### Claim 14 (depends on 12) The method as recited in claim 12, wherein positioning the light sensor includes positioning the light sensor at a same position at different times to enable determination of respective PPG signals, and comparing the PPG signals to determine PPG changes in the blood vessel, and wherein positioning the light sensor includes employing a robot having the light sensor mounted thereon and moving the robot to permit repeatable positioning of the light sensor at different times. ### Claim 15 (depends on 12) The method as recited in claim 12, further comprising accounting for motion in the blood vessel to register PPG maps, wherein the accounting includes providing a grid overlaid on the image signal of the blood vessel, wherein each portion of the grid includes a tracked point to follow to determine the motion of the blood vessel.