# US 9,750,505 B2 · Medical device for modification of left atrial appendage and related systems and methods > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,505 B2 - Document ID: US9750505B2 - Status: Granted - Kind: B2 - Application number: 14/287,103 - Filed: 2014-05-26 - Published: 2014-11-20 - Granted: 2017-09-05 - Earliest claimed: 2009-01-08 - Assignees: Coherex Medical, Inc. - Applicants: Coherex Medical, Inc. - Inventors: Scott D. Miles; Daryl R. Edmiston; Clark C. Davis - Web page: https://patentgrep.com/patent/US9750505B2 ## CPC - A61B 17/1215: {comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated} - A61B 17/00234: {for minimally invasive surgery (A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence)} - A61B 17/0057: {Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009)} - A61B 17/0401: {Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors (A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811)} - A61B 17/06166: {Sutures (suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M)} - A61B 17/12022: {Occluding by internal devices, e.g. balloons or releasable wires (plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20)} - A61B 17/12031: {complete occlusion} - A61B 17/1204: {temporary occlusion} - A61B 17/12122: {within the heart (for closing a cardiac septal defect A61B17/0057)} - A61B 17/12131: {characterised by the type of occluding device} - A61B 17/12159: {Solid plugs; being solid before insertion} - A61B 17/12172: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)} - A61B 17/122: Clamps or clips, e.g. for the umbilical cord {(for the vas deferens A61F6/206)} - A61B 17/0487: {Suture clamps, clips or locks, e.g. for replacing suture knots; Instruments for applying or removing suture clamps, clips or locks (suture anchors A61B17/0401; wound clamps or clips A61B17/08; ligaturing clamps or clips A61B17/122)} - A61B 2017/00243: {cardiac} - A61B 2017/00526: {Methods of manufacturing} - A61B 2017/00575: {for closure at remote site, e.g. closing atrial septum defects} - A61B 2017/00579: {Barbed implements} - A61B 2017/00588: {Rigid or stiff implements, e.g. made of several rigid parts linked by hinges} - A61B 2017/00592: {Elastic or resilient implements} - A61B 2017/00597: {Implements comprising a membrane} - A61B 2017/00601: {Implements entirely comprised between the two sides of the opening} - A61B 2017/0061: {Implements located only on one side of the opening} - A61B 2017/00632: {Occluding a cavity, i.e. closing a blind opening} - A61B 2017/00867: {shape memory effect} - A61B 2017/00884: {enhancing wound closure} - A61B 2017/0409: {Instruments for applying suture anchors} - A61B 2017/0412: {having anchoring barbs or pins extending outwardly from suture anchor body} - A61B 2017/0414: {having a suture-receiving opening, e.g. lateral opening} - A61B 2017/0437: {the barbs being resilient or spring-like} - A61B 2017/0446: {Means for attaching and blocking the suture in the suture anchor} - A61B 2017/0448: {Additional elements on or within the anchor} - A61B 2017/0459: {Multiple holes in the anchor through which the suture extends and locking the suture when tension is applied} - A61B 2017/0464: {for soft tissue} - A61B 2017/1205: {Introduction devices} - Y10T 29/49826: Assembling or joining - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION ## Abstract A medical device and system for modifying a left atrial appendage (“LAA”), as well as related methods, are provided. In accordance with one embodiment, a medical device includes a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure. Each frame segment includes a hub portion and at least one leg portion, the hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member, and the at least one leg portion extending from the hub portion. With this arrangement, a tissue growth member is coupled to the frame segments. ## Claims ### Claim 1 A medical device for modifying an atrial appendage, the medical device comprising: a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the plurality of frame segments configured to be positioned within one of the notches of the at least one ring member to collectively form a frame structure, each frame segment including: a hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member; and at least one leg portion extending from the hub portion; and a tissue growth member coupled with the plurality of frame segments to define a substantially convex surface and a substantially concave surface. ### Claim 2 (depends on 1) The medical device of claim 1, wherein the tissue growth member comprises a porous material. ### Claim 3 (depends on 1) The medical device of claim 1, wherein the tissues growth member comprises expanded polytetrafluoroethylene. ### Claim 4 (depends on 1) The medical device of claim 1, wherein the plurality of frame segments are formed of a nickel-titanium alloy. ### Claim 5 (depends on 1) The medical device of claim 1, wherein the at least one leg portion comprises an expanding leg and a collapsing leg each extending from its associated hub portion. ### Claim 6 (depends on 1) The medical device of claim 1, wherein the plurality of frame segments are cooperatively configured to define a central opening therethrough. ### Claim 7 (depends on 1) The medical device of claim 1, wherein at least a portion of each of the at least one leg portion is positioned adjacent the convex surface of the tissue growth member. ### Claim 8 (depends on 7) The medical device of claim 7, wherein at least a portion of each of the at least one leg portion is positioned adjacent the concave surface of the tissue growth member. ### Claim 9 (depends on 1) The medical device of claim 1, wherein each frame segment includes a coupling mechanism configured to attach to the tissue growth member. ### Claim 10 (depends on 1) The medical device of claim 1, wherein the at least one leg portion comprises a coupling mechanism configured to attach to the tissue growth member. ### Claim 11 (depends on 1) The medical device of claim 1, wherein the tissue growth member comprises a first portion and a second portion, the second portion positioned over a proximal side of the first portion. ### Claim 12 (depends on 11) The medical device of claim 11, wherein the first portion comprises a porous foam material and the second portion comprises expanded polytetrafluoroethylene. ### Claim 13 (depends on 11) The medical device of claim 11, wherein the first portion is coupled to the frame segments and extends along the frame segments between a proximal end and a distal end of the first portion, the second portion extending over the first portion to cover a proximal side of the first portion and extends distally toward the distal end of the first portion such that the distal end of the first portion extends more distal than a distal end of the second portion. ### Claim 14 (depends on 11) The medical device of claim 11, wherein the first portion extends more distal than the second portion such that an outer surface of the first portion at a distal portion of the tissue growth member is exposed. ### Claim 15 A medical device system comprising: a medical device comprising: a plurality of frame segments coupled with at least one ring member, the at least one ring member having an inner surface defining notches radially spaced therein, each of the plurality of frame segments configured to be positioned within one of the notches of the at least one ring member to form a frame structure, each frame segment including: a hub portion having an upper surface configured to be captured in one of the notches defined in the at least one ring member; and at least one leg portion extending from the hub portion; a tissue growth member coupled with the plurality of frame segments to define a substantially convex surface and a substantially concave surface; a catheter; and a pusher member configured to displace the medical device relative to the catheter. ### Claim 16 (depends on 15) The medical device system of claim 15, wherein the pusher member is releaseably coupled with the medical device. ### Claim 17 (depends on 15) The medical device system of claim 15, wherein the pusher member is threadably coupled with the medical device. ### Claim 18 (depends on 15) The medical device system of claim 15, wherein the tissue growth member comprises a first portion and a second portion, the second portion positioned over a proximal side of the first portion. ### Claim 19 (depends on 18) The medical device system of claim 18, wherein the first portion extends more distal than the second portion such that an outer surface of the first portion at a distal portion of the tissue growth member is exposed. ### Claim 20 (depends on 18) The medical device of claim 18, wherein the first portion of the tissue growth member comprises a porous foam material. ### Claim 21 (depends on 18) The medical device of claim 18, wherein the second portion of the tissues growth member comprises expanded polytetrafluoroethylene. ### Claim 22 A method of forming a medical device, the method comprising: forming a plurality of frame segments, each frame segment including a hub portion and at least one leg portion; coupling the hub portion of each of the plurality of frame segments with at least one ring member such that the at least one ring member includes an inner surface defining notches radially spaced therein so that an upper surface of the hub portion of each of the plurality of frame segments is captured in one of the notches of the at least one ring member; and coupling a tissue growth member with the plurality of frame segments. ### Claim 23 (depends on 22) The method according to claim 22, wherein coupling a tissue growth member with the plurality of frame segments further includes forming a substantially concave surface and a substantially convex surface with the tissue growth member. ### Claim 24 (depends on 22) The method according to claim 22, wherein coupling a tissue growth member comprises attaching a first portion of the tissue growth member to the plurality of frame segments. ### Claim 25 (depends on 24) The method according to claim 24, wherein the coupling a tissue growth member comprises attaching a second portion of the tissue growth member to a proximal side of the first portion of the tissue growth member such that a distal outer portion of the first portion is exposed. ### Claim 26 (depends on 25) The method according to claim 25, wherein the coupling a tissue growth member comprises attaching the first portion being a porous foam material and attaching the second portion being an expanded polytetrafluoroethylene. ### Claim 27 (depends on 22) The method according to claim 22, further comprising forming the hub portion of a given frame segment to be substantially coplanar with the at least one leg portion. ### Claim 28 (depends on 22) The method according to claim 22, wherein forming a plurality of frame segments includes cutting each frame segment from a substantially flat sheet of nickel-titanium alloy.