# US 9,750,437 B2 · Determination of neuronal action potential amplitude based on multidimensional differential geometry > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,750,437 B2 - Document ID: US9750437B2 - Status: Granted - Kind: B2 - Application number: 14/618,023 - Filed: 2015-02-10 - Published: 2015-08-13 - Granted: 2017-09-05 - Earliest claimed: 2014-02-11 - Assignees: MED-EL Elektromedizinische Geraete GmbH - Applicants: MED-EL Elektromedizinische Geraete GmbH - Inventors: Konrad Schwarz; Philipp Spitzer; Stefan Strahl - Web page: https://patentgrep.com/patent/US9750437B2 ## CPC - A61B 5/125: {objective methods} - A61B 5/0031: {Implanted circuitry} - A61B 5/4041: {Evaluating nerves condition} - A61B 5/6817: {Ear canal} - A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)} - A61N 1/36038: {Cochlear stimulation} - A61N 1/36039: {fitting procedures} - A61B 5/062: {using magnetic field} - A61B 5/063: {using impedance measurements} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Arrangements are described for determining a physiological characteristic of the auditory pathway (as whole or selected parts such as an inner ear). Electrical stimulation pulses are delivered to inner ear neural tissue and corresponding tissue response signals are developed by measuring over time response of the auditory pathway to each electrical stimulation pulse, with each tissue response signal forming a response curve including at least one physiological landmark such as a local maximum and a local minimum. A multi-dimensional polynomial is fit over the tissue response signals, and calculation starting points are defined based on prominent physiologic landmarks such as a local maximum and a local minimum for one selected tissue response signal. A line of minimum principal curvature of the multi-dimensional polynomial over the plurality of tissue response signals that intersect the calculation starting points is calculated to determine a physiological characteristic of the auditory pathway. ## Claims ### Claim 1 A fitting system including at least one hardware-implemented processor for fitting a cochlear implant having an implanted electrode array with a plurality of stimulation electrodes to an implanted patient based on determining a physiological characteristic of the auditory pathway in the implanted patient, the system comprising: a tissue stimulation module in communication with the cochlear implant via a control interface and configured to generate a plurality of electrical stimulation pulses to the one or more stimulation electrodes for delivery to auditory neural tissue of the inner ear of the implanted patient; one or more response measurement electrodes on the implanted electrode array configured to measure neural response over time of the auditory pathway to the electrical stimulation pulses to develop a plurality of tissue response signals, wherein each tissue response signal forms a response curve; and a response calculation module including at least one hardware-implemented processor and coupled to the response measurement electrodes to receive the tissue response signals and configured to determine the physiological characteristic by: i. fitting a multi-dimensional polynomial over the plurality of tissue response signals, ii. defining calculation starting points for one selected tissue response signal, iii. calculating a line of minimum principal curvature of the multi-dimensional polynomial over the plurality of tissue response signals that intersect the calculation starting points to determine the physiological characteristic of the auditory pathway, and iv. providing fitting instructions via the control interface to the cochlear implant based on the physiological characteristic of the auditory pathway to fit operation of the cochlear implant to the implanted patient. ### Claim 2 (depends on 1) The system according to claim 1, wherein the physiological characteristic includes an amplitude growth function. ### Claim 3 (depends on 2) The system according to claim 2, wherein the multi-dimensional polynomial includes a post-stimulus time dimension and a stimulus intensity dimension. ### Claim 4 (depends on 1) The system according to claim 1, wherein the physiological characteristic includes a tissue recovery function. ### Claim 5 (depends on 4) The system according to claim 4, wherein the multi-dimensional polynomial includes a post-stimulus time dimension and an inter-stimulation pulse interval dimension. ### Claim 6 (depends on 1) The system according to claim 1, wherein the physiological characteristic includes a spread of excitation function. ### Claim 7 (depends on 6) The system according to claim 6, wherein the multi-dimensional polynomial includes a spatial distance dimension and an inter-stimulation pulse interval dimension. ### Claim 8 (depends on 1) The system according to claim 1, wherein the physiological characteristic includes a physiological characteristic resulting in a continuous function of the signal selected from the group of an amplitude growth function, a tissue recovery function, and a spread of excitation function. ### Claim 9 (depends on 1) The system according to claim 1, wherein the response calculation module uses a local maximum and a local minimum of the one selected tissue response signal to define the calculation starting points. ### Claim 10 (depends on 1) The system according to claim 1, wherein the response calculation module calculates the line of minimum principal curvature iteratively. ### Claim 11 (depends on 1) The system according to claim 1, wherein the response calculation module further outputs multi-dimensional fit closeness as a function of the carrier of the measurements. ### Claim 12 (depends on 1) The system according to claim 1, wherein the multi-dimensional polynomial has a fixed degree. ### Claim 13 (depends on 1) The system according to claim 1, wherein the multi-dimensional polynomial has a variable degree. ### Claim 14 (depends on 1) The system according to claim 1, wherein the tissue response signals include electrically evoked compound action potential (eCAP) signals. ### Claim 15 A computer implemented method using at least one hardware-implemented processor for fitting a cochlear implant having an implanted electrode array with a plurality of stimulation electrodes to an implanted patient based on determining a physiological characteristic of the auditory pathway in the implanted patient, the method comprising: delivering a plurality of electrical stimulation pulses from a tissue stimulation module via a control interface to the stimulation electrodes to stimulate inner ear neural tissue; developing a plurality of tissue response signals with one or more response measurement electrodes on the implanted electrode array by measuring over time a corresponding neural response of the inner ear neural tissue to each electrical stimulation pulse, wherein each tissue response signal forms a response curve; using a response calculation module including at least one hardware-implemented processor to receive the plurality of tissue response signals and determine the physiological characteristic by: i. fitting a multi-dimensional polynomial over the plurality of tissue response signals; ii. defining calculation starting points for one selected tissue response signal; iii. calculating a line of minimum principal curvature of the multi-dimensional polynomial over the plurality of tissue response signals that intersect the calculation starting points to determine the physiological characteristic of the auditory pathway; and iv. providing fitting instructions via the control interface to the cochlear implant based on the physiological characteristic of the auditory pathway to fit operation of the cochlear implant to the implanted patient. ### Claim 16 (depends on 15) The method according to claim 15, wherein the physiological characteristic includes an amplitude growth function. ### Claim 17 (depends on 16) The method according to claim 16, wherein the multi-dimensional polynomial includes a post-stimulus time dimension and a stimulus intensity dimension. ### Claim 18 (depends on 15) The method according to claim 15, wherein the physiological characteristic includes a tissue recovery function. ### Claim 19 (depends on 18) The method according to claim 18, wherein the multi-dimensional polynomial includes a post-stimulus time dimension and an inter-stimulation pulse interval dimension. ### Claim 20 (depends on 15) The method according to claim 15, wherein the physiological characteristic includes a spread of excitation function. ### Claim 21 (depends on 15) The method according to claim 15, wherein the physiological characteristic includes a physiological characteristic resulting in a continuous function of the signal selected from the group of an amplitude growth function, a tissue recovery function, and a spread of excitation function. ### Claim 22 (depends on 21) The method according to claim 21, wherein the multi-dimensional polynomial includes a spatial distance dimension and an inter-stimulation pulse interval dimension. ### Claim 23 (depends on 15) The method according to claim 15, wherein the line of minimum principal curvature is calculated iteratively. ### Claim 24 (depends on 15) The method according to claim 15, further comprising: outputting multi-dimensional fit closeness as a function of the carrier of the measurements. ### Claim 25 (depends on 15) The method according to claim 15, wherein the multi-dimensional polynomial has a fixed degree. ### Claim 26 (depends on 15) The method according to claim 15, wherein the multi-dimensional polynomial has a variable degree. ### Claim 27 (depends on 15) The method according to claim 15, wherein the tissue response signals include electrically evoked compound action potential (eCAP) signals.