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US 9,746,475 B2Granted
Antibody and antibody mimetic for visualization and ablation of endogenous proteins
AssigneeUniversity of Southern California
InventorsDon B. Arnold, Richard W. Roberts, Garrett G. Gross, Rudy Mora, Jason Junge
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Abstract
Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic that recognizes the endogenous or target protein.
Claims37
A polynucleotide comprising:
- (1) a nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises
- (a) a binding moiety for recognizing an endogenous protein, and
- (b) a transcription factor;
- and
- (2) a transcription regulatory element operatively linked to the nucleic acid sequence, wherein the transcription regulatory element regulates the transcription of the binding moiety and the transcription factor regulates the activity of the transcription regulatory element.
2 more elements
Dependencies are inferred from the claim text.