Compositions and methods for treating pathological calcification and ossification
AssigneeYale University
InventorsDemetrios Braddock, Ronald Albright
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Abstract
The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.
Claims13
A method of reducing or preventing progression of pathological calcification in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a polypeptide comprising a soluble ecto-nucleotide pyrophosphate/phosphodiesterase-1 (NPP1) polypeptide, said soluble NPP1 polypeptide lacking a domain comprising 4 to 20 sequential aspartic acid residues, whereby pathological calcification in said subject is reduced or progression of pathological calcification in said subject is prevented.
Dependencies are inferred from the claim text.