Biosensor device and system

A cartridge for sensing biological samples comprising:

• a housing configured to interface with one or more external devices;
• a semiconductor chip having integrated therein an array of sensors;
• a sealing block spaced apart from the chip to form a gap therebetween;
• and
• an array of wells open on one side of a planar substrate to receive the samples, wherein the sealing block and chip are arranged to move relative to one another between a non-sealing position and a sealing position to close the gap so as to isolate the wells from each other;
• and
• an actuator which urges the sealing block into the sealing position as the cartridge is removed from the one or more external devices;
• wherein the actuator is movable from a first position to a second position, the sealing block is in the non-sealing position when the actuator is in the first position, and the sealing block is in the sealing position being pushed by the actuator when the actuator is in the second position.