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US 9,737,593 B2Granted
Carbon nanotube compositions and methods of use thereof
AssigneeYale University
InventorsTarek M. Fahmy, Lisa D. Pfefferle, Gary L. Haller
Life of this patent
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Abstract
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.
Claims14
A carbon nanotube bundle comprising
- acid washed carbon nanotubes, the nanotubes having bound to or present on the surface
- one or more T cell receptor activators selected from the group consisting of antigens bound to WIC molecules and antibodies or fragments thereof that crosslink the T cell receptor/CD3 complex,
- one or more T cell costimulatory or T cell adhesion molecules, and
- polymeric nanoparticles comprising a cytokine encapsulated therein.
1 more element
Dependencies are inferred from the claim text.