Methods of treating neurological and other disorders using enantiopure deuterium-enriched bupropion
AssigneeDeuteRx, LLC
InventorsSheila DeWitt, Vincent Jacques, Leonardus H. T. van der Ploeg
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Abstract
The invention provides enantiopure deuterium-enriched bupropion, pharmaceutical compositions, and methods of treating neurological disorders, movement disorders, cardiovascular disorders, metabolic disorders, and other disorders using enantiopure deuterium-enriched bupropion. A preferred aspect of the invention provides methods of treating obesity and sexual dysfunction using enantiopure deuterium-enriched bupropion.
Claims9
A method of treating obesity, comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of Formula I-A having an optical purity of at least 75% enantiomeric excess to treat the obesity, wherein Formula I-A is represented by:
- or a pharmaceutically acceptable salt thereof, wherein Z is H or D, provided that the abundance of deuterium in Z is at least 60%.
A method of treating obesity, comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of Formula II-A having an optical purity of at least 75% enantiomeric excess to treat the obesity, wherein Formula II-A is represented by:
- or a pharmaceutically acceptable salt thereof, wherein Z is H or D, provided that the abundance of deuterium in Z is at least 60%.
Dependencies are inferred from the claim text.