Methods and devices for open-bed atmospheric collection for supercritical fluid chromatography

A supercritical fluid chromatography system comprising:

• a first pump for pumping a first flow stream comprising a compressible fluid;
• a second pump for pumping a second flow stream comprising a modifier fluid, the second pump in parallel with the first pump;
• a column located in a combined flow stream, the column located downstream of the first and second pumps, the combined flow stream comprising the first flow stream, the second flow stream, and a sample;
• a detector located downstream of the column;
• a gas-liquid separator located downstream of the detector, the gas-liquid separator configured to receive and separate the combined flow stream into a compressible fluid flow and a remaining flow, the gas-liquid separator further configured to vent a majority of the compressible fluid while maintaining a majority of the sample to avoid sample loss and cross-contamination resulting in the remaining flow;
• a collector arm located downstream of the gas-liquid separator positioned to receive the remaining flow;
• a collector arm adapter coupled to the collector arm, the collector arm adapter configured to reduce aerosols when the remaining flow is at atmospheric conditions;
• and
• an open bed XY type collector located downstream of the collector arm adapter and positioned such that the remaining flow is directed to pass through the collector arm and into the open bed XY type collector.