Endosseous implant
AssigneesUniversite De Geneve, Ecole Polytechnique Federale de Lausanne
InventorsPierre Descouts, Björn-Owe Aronsson, Michael Grätzel, Carine Viornery, Peter Péchy
Life of this patent
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Abstract
Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.
Claims19
A pharmaceutically acceptable amide of a compound corresponding to the formula (I):
- A-[P(O)(OH)2]p (I),
- wherein:
- A is A1, wherein Al is a residue of a linear, branched or cyclic, saturated or unsaturated, hydrocarbon with n carbon atoms, carrying p phosphonic acid groups,
- wherein said residue is substituted by hydroxyl and/or carboxyl or said residue is unsubstituted, and
- wherein said residue is interrupted by one or more oxygen and/or sulphur and/or nitrogen atoms or said residue is not interrupted, and
- wherein n is a number from 4 to 70, and
- p is 3 to 6;
- or
- A is A2, wherein A2 is a residue of an amino acid or of a sequence of amino acids respectively of a protein or of a polypeptide or a residue of a specific drug molecule, wherein each residue A2 carries p phosphonic acid groups, and p is 3 to 6.
A pharmaceutically acceptable amide of a compound corresponding to the formula (I):
- A-[P(O)(OH)2]p (I),
- wherein
- A is a residue of a linear, branched or cyclic, saturated or unsaturated, hydrocarbon with n carbon atoms, carrying p phosphonic acid groups,
- wherein said residue is substituted by hydroxyl and/or carboxyl or said residue is unsubstituted, and
- wherein said residue is interrupted by one or more oxygen and/or sulphur and/or nitrogen atoms or said residue is not interrupted, and
- wherein n is a number from 1 to 70, and p is 2.
Dependencies are inferred from the claim text.