Nitroso compounds as nitroxyl donors and methods of use thereof
AssigneeCardioxyl Pharmaceuticals, Inc.
InventorsLisa Marie Frost, Stephen Martin Courtney, Frederick Arthur Brookfield, Vincent Jacob Kalish
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Abstract
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
Claims11
A compound of the formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- each R1 and R2 is independently a moiety of the formula C1-C4alkyl-O—C1-C4alkyl- or acyl-O—C1-C4alkyl;
- D is selected from the group consisting of alkyl-C(O)—, substituted alkyl-C(O)—, perhaloalkyl-C(O)—, alkenyl-C(O)—, substituted alkenyl-C(O)—, alkynyl-C(O)—, substituted alkynyl-C(O)—, aryl-C(O)—, substituted aryl-C(O)—, heteroaryl-C(O)—, substituted heteroaryl-C(O)—, and heterocyclyl-C(O)—.
A compound or a pharmaceutically acceptable salt thereof, wherein the compound is
A compound or a pharmaceutically acceptable salt thereof, wherein the compound is
Dependencies are inferred from the claim text.