Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin
AssigneesDuke University, Children's Medical Center Corporation
InventorsJames Whittle, Stephen C. Harrison, Barton F. Haynes, Hua-Xin Liao, M. A. Moody, Thomas B. Kepler, Aaron G. Schmidt
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Abstract
The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides methods, compositions, and kits featuring the novel antibody and its use in preventing or treating influenza infection.
Claims22
An anti-influenza recombinant monoclonal antibody or antigen binding fragment thereof that specifically binds influenza hemagglutinin (HA) at residues 136, 137 and 226 of the HA polypeptide sequence and thereby reduces or inhibits influenza hemagglutinin binding to sialic acid, wherein the anti-influenza antibody or antigen binding fragment thereof comprises at least one sequence selected from the group consisting of:
- a variable heavy (VH) chain sequence SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, or one or more heavy chain CDR regions present in a variable heavy (VH) chain amino acid sequence of SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, or SEQ ID NO:
- 12;
- and
- a variable light (VL) chain sequence SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, or one or more light chain CDR regions present in a variable light (VL) chain amino acid sequence of SEQ ID NO:
- 13, SEQ ID NO:
- 14, SEQ ID NO:
- 15, or SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.