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US 9,717,761 B2Granted
Stem cell-derived neural cells for cell therapy in neurological disorders
AssigneeRamot at Tel-Aviv University Ltd.
InventorsSandu Pitaru, Javier Ganz, Daniel Offen, Eldad Melamed
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Abstract
The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.
Claims10
A method for inducing selective differentiation of oral mucosa stem cells (OMSC) into neuron-supporting glial cells, comprising:
- (a) obtaining oral mucosa stem cells (OMSC) from oral mucosa;
- (b) incubating the OMSC of (a) in a pre-differentiating medium, comprising N-2 supplement, basic fibroblast growth factor 2 (bFGF) and epidermal growth factor (EGF);
- and
- (c) after incubation of the OMSC in (b), replacing the pre-differentiation medium of (b) with a differentiating medium comprising dibutyryl cyclic adenosine monophosphate (dbcAMP), IBMX (3-Isobutyl-1-methylxanthine), neuregulin, and platelet-derived growth factor (PDGF) and incubating the OMSC from (b) in the differentiation medium to selectively differentiate OMSC into neuron-supporting glial cells secreting neurotrophic factors.
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