Recombinant proteins of parapdxvirus ovis and pharmaceutical compositions therefrom
AssigneeAiCuris GmbH & Co. KG
InventorsOlaf Weber, Sonja Maria Tennagels, Angela Siegling, Tobias Schlapp, Andrew Allan Mercer, Stephen Bruce Fleming, Hans-Dieter Volk
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Abstract
The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
Claims11
A method for down-regulating cross-presentation of an antigen with a MHC Class I molecule on a cell in a subject, comprising administering to the subject a recombinant protein encoded by a polynucleotide selected from the group consisting of:
- a polynucleotide comprising the sequence of nucleotide residues 122616 to 136025 of SEQ ID NO:1 (PPVO insert of VVOV 82), or a complementary sequence thereof;
- and
- a polynucleotide comprising the sequence of nucleotide residues 10264 to 20003 of SEQ ID NO:1 (PPVO insert of VVOV 215), or a complementary sequence thereof,
- thereby down-regulating MHC Class I cross-presentation of an antigen on a cell in the subject,
- wherein the subject has hepatitis, papillomatosis, herpes virus infection, liver fibrosis, HIV infection, AIDS, or influenza.
A method for down-regulating cross-presentation of an antigen with a MHC Class I molecule on a cell in a subject, comprising administering to the subject a polynucleotide or a vector, a virus, or a host cell comprising the polynucleotide, wherein the polynucleotide is selected from the group consisting of:
- a polynucleotide comprising the sequence of nucleotide residues 122616 to 136025 of SEQ ID NO:1 (PPVO insert of VVOV 82), or a complementary sequence thereof;
- and
- a polynucleotide comprising the sequence of nucleotide residues 10264 to 20003 of SEQ ID NO:1 (PPVO insert of VVOV 215), or a complementary sequence thereof,
- thereby down-regulating MHC Class I cross-presentation of an antigen on a cell in the subject,
- wherein the subject has hepatitis, papillomatosis, herpes virus infection, liver fibrosis, HIV infection, AIDS, or influenza.
Dependencies are inferred from the claim text.