Compositions and methods for the treatment of hepatic diseases and disorders
AssigneeLabyrinth Holdings, LLC
InventorElizabeth McKenna
Life of this patent
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Abstract
The disclosure provides oral compositions and methods of using such compositions in treating subjects infected with one or more hepatic disorders. The compositions include lysates or cell wall extracts of one or more gram positive bacteria, exhibit particular activity against hepatitis C virus (HCV), and may be useful in treating those infected with HCV as well as other hepatic diseases or disorders. Also described are methods of treating a hepatic disease or disorder by administering a therapeutically effective amount of at least one therapeutically active agent capable of upregulating or downregulating the Complement system pathway, wherein the therapeutically active agent enhances the formation of one or more convertase enzymes.
Claims8
A method of treating hepatitis A, hepatitis B, or hepatitis C infection in a subject so affected, the method comprising sublingually or buccally administering to the subject a therapeutically effective amount of a composition comprising:
- (a) a lysate and/or a cell wall extract from a Gram-positive bacterium of the Lactobacillus genus, or a pharmaceutically acceptable salt thereof;
- (b) a promoter;
- and
- (c) an optional carrier,
- wherein the composition is formulated to completely dissolve in not less than 1 minute after administration.
A method of treating a hepatitis infection in a subject so affected, the method comprising:
- sublingually or buccally administering to the subject a therapeutically effective amount of a composition comprising:
- (a) a lysate and/or a cell wall extract from a Gram-positive bacterium of the Lactobacillus genus, or a pharmaceutically acceptable salt thereof;
- (b) a promoter;
- and
- (c) an optional carrier,
- wherein the composition is formulated to completely dissolve in not less than 1 minute after administration.
A method of activating Toll-Like Receptor (TLR) signaling in a subject, the method comprising:
- sublingually or buccally administering to a subject in need thereof an effective amount of a composition comprising:
- (a) a lysate and/or cell wall extract from a Gram-positive bacteria of the Lactobacillus genus, or a pharmaceutically acceptable salt thereof;
- (b) a promoter;
- and
- (c) an optional carrier,
- wherein the composition is formulated to completely dissolve in not less than 1 minute after administration, and
- wherein the lysate and/or cell wall extract is present in an amount effective to activate TLR signaling in the subject.
Dependencies are inferred from the claim text.