Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues

A method for at least one of characterizing, diagnosing, and treating a neurological health issue in at least a subject, the method comprising:

• for each of an aggregate set of samples from a population of subjects:
• determining a microorganism nucleic acid sequence, comprising:
• identifying primers for nucleic acid sequences associated with the neurological health issue,
• fragmenting nucleic acid material from the biological sample, and
• amplifying the fragmented nucleic acid material using the identified primers;
• and
• determining an alignment of the microorganism nucleic acid sequence to a reference nucleic acid sequence associated with the neurological health issue;
• generating a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects based on the;
• receiving a supplementary dataset, associated with at least a subset of the population of subjects, wherein the supplementary dataset is informative of characteristics associated with the neurological health issue;
• transforming the supplementary dataset and features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset into a characterization model of the neurological health issue;
• based upon the characterization model, generating a therapy model configured to correct the neurological health issue;
• and
• at an output device associated with the subject, providing a therapy to the subject with the neurological health issue, upon processing a sample from the subject with the characterization model, in accordance with the therapy model, wherein the therapy modulates microbiome composition to improve a state of the neurological health issue.