US 9,708,371 B2 · Treatments for gastrointestinal disorders

Abstract

The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited to, irritable bowel syndrome (IBS), gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia, visceral pain, gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), disorders and conditions associated with constipation, and other conditions and disorders are described herein, using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

Claims28

Dependent claims

A peptide or a pharmaceutically acceptable salt thereof, wherein the peptide comprises the amino acid structure of:

and the peptide activates the guanylate cyclase C receptor.

Dependencies are inferred from the claim text.

Facts

Application

14/239,178Filed 17 Aug 2012 · us provisional application

Priority

17 Aug 2011

Published

US 2015/0094272 A12 Apr 2015

Granted

18 Jul 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification22 codes

C07K 7/08
Linear peptides containing only normal peptide links: having 12 to 20 amino acids
A61K 38/10
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 12 to 20 amino acids
A61K 38/12
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: cyclic peptides , e.g. bacitracins; Polymyxins; Gramicidins…
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…

Treatments for gastrointestinal disorders

Life of this patent

Treatments for gastrointestinal disorders

Life of this patent

Abstract

Claims28