Echothiophate iodide process
AssigneeShilpa Medicare Limited
InventorsNagnnath Kokare, Venkatanarayana Bathula, Akshaykant Chaturvedi
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for preparation of Echothiophate Iodide (I). Echothiophate Iodide (I) obtained by the process of the present invention is obtained as new crystalline form designated as Form-SET. The process for preparation of Echothiophate Iodide (I) according to present invention is an ecofriendly process that avoids the use of hazardous solvent systems and provides Echothiophate Iodide (I) of high purity. Pharmaceutical composition of the said crystalline Form-SET of Echothiophate Iodide (I) of high purity is useful in the treatment of ocular disorders like Glaucoma.
Claims7
A process for preparation of Echothiophate Iodide (I),
- comprising the steps of:
- a) providing a solution of 2-(dimethylamino) ethane thiol or its salt and a base in an organic solvent;
- b) optionally heating the reaction mixture to 50-70° C. and obtaining a residual mass;
- c) treating the step a) or b) material with diethyl halogen phosphate in an organic solvent having boiling point greater than 100° C. to obtain S-2-(dimethyl amino) ethyl O,O-diethyl phosphorothioate of Formula (II);
- d) reacting S-2-(dimethyl amino)ethyl O,O-diethyl phosphoro thioate (II) of step c) with methyl iodide in an organic solvent;
- and
- e) isolating pure Echothiophate Iodide (I).
Crystalline Echothiophate Iodide (I), designated as Form-SET characterized by X-ray powder diffraction pattern- having at least five 2θ° peaks selected from the XRPD peak set of 14.4, 15.0, 18.2, 18.7, 21.1, 21.3, 23.3, 25.1and 31.8±0.2θ°.
Dependencies are inferred from the claim text.