Ingenol-3-acylates III and ingenol-3-carbamates

A compound of the general formula I

• wherein R is heterocycloalkyl or heterocycloalkenyl, wherein said heterocycloalkyl or heterocycloalkenyl are optionally substituted by one or more substituents independently selected from R8;
• or R is X;
• R8 represents halogen, cyano or hydroxyl;
• or R8 represents (C1-C4)alkyl, (C2-C4)alkenyl, aryl, heteroaryl, (C3-C7)-cycloalkyl or heterocycloalkyl, wherein said C1-C4)alkyl, (C2-C4)alkenyl, aryl, heteroaryl, (C3-C7)-cycloalkyl or heterocycloalkyl are optionally substituted by one or more substituents independently selected from R10;
• or R8 represents —NRaCORb, —COORc, —OCORa, —CONRaRb, —OCONRaRb, —NRaCOORb, —NRaCONRaRb, —NRaSO2NRaRb, —NRaSO2Rb, —SO2NRaRb, —SO2Ra, —S(O)Ra, —ORa, —SRa, ═O, ═N—ORa, —O—N═CRaRb, NRaRb or —C(O)N(Ra)O—Rb;
• R10 represents halogen, cyano, hydroxy, (C1-C4)-alkyl, (C1-C4)alkoxy, halo(C1-C4)alkyl, halo(C1-C4)alkoxy, hydroxy(C1-C4)alkyl, cyano(C1-C4)alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —NRaCORb, —COORc, —OCORa, —CONRaRb, —OCONRaRb, —NRaCOORb, —NRaCONRaRb, —NRaSO2NRaRb, —NRaSO2Rb, —SO2NRaRb, —SO2Ra, —S(O)Ra, —ORa, —SRa or ═O;
• Ra and Rb represent hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, hydroxy(C1-C4)alkyl, cyano(C1-C4)alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl;
• Rc represents hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, hydroxy(C1-Cx)alkyl, cyano(C1-Cx)alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl;
• X represents —NR11R12;
• wherein R11 and R12 independently represent hydrogen, or
• wherein R11 and R12 independently represents (C1-C6)alkyl, (C2-C6)alkenyl or (C2-C6)alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, heterocycloalkenylalkyl, alkylcycloalkyl, alkylcycloalkenyl, alkylaryl, alkylheteroaryl or alkylheterocycloalkyl, wherein said (C1-C6)alkyl, (C2-C6)alkenyl or (C2-C6)alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocycloalkyl, heterocycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, heterocycloalkenylalkyl, alkylcycloalkyl, alkylcycloalkenyl, alkylaryl, alkylheteroaryl or alkylheterocycloalkyl are optionally substituted by one or more substituents independently selected from R13;
• R13 represents halogen, cyano or hydroxyl,
• or R13 represents (C1-C4)alkyl, (C2-C4)alkenyl, aryl, (C3-C7)cycloalkyl, heteroaryl or heterocycloalkyl, wherein said (C1-C4)alkyl, (C2-C4)alkenyl, aryl, (C3-C7)cycloalkyl, heteroaryl or heterocycloalkyl are optionally substituted by one or more substituents selected from R14,
• or R13 represents —NRdCORe, —COORf, —OCORd, —CONRdRe, —OCONRdRe, —NRdCOORe, —NRdCONRdRe, —NRdSO2Re, —NRdSO2NRdRe, —SO2NRdRe, —SO2Rd, —S(O)Rd, —ORd, —SRd, ═O, ═N—ORd, —O—N═CRdRe, —NRdRe or —C(O)N(Rd)—ORe
• wherein Rd and Re independently represents hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, hydroxy(C1-C4)alkyl, cyano(C1-C4)alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl;
• Rf represents hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxyl(C1-C4)alkyl, hydroxy(C1-C4)alkyl, cyano(C1-C4)alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl;
• R14 represents halogen, hydroxyl, cyano, (C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkyl, halo(C1-C4)alkoxy, hydroxy(C1-C4)alkyl, cyano(C1-C4)alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —NRdCORe, —COORf, —OCORd, —CONRdRe, —OCONRdRe, —NRdCOORe, —NRdCONRdRe, —NRdSO2Re, —NRdSO2NRdRe, —SO2NRdRe, —SO2Rd, —S(O)Rd, —ORd, —SRd or ═O;
• and
• pharmaceutically acceptable salts, hydrates and solvates thereof.