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US 9,707,305 B2Granted
Formulas for diagnosing and treating hormone-dependent cancers and cancers of the organs responsible for steroid hormone synthesis
AssigneeCommissariat A L'energie Atomique Et Aux Energies Alternatives
InventorsJuliette Merian, Raphaël Boisgard, Bertrand Tavitian, Isabelle Texier-Nogues
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Abstract
The present invention relates to a formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, to its preparation method and to the use of this formulation for treating or diagnosing hormone-dependent cancers or cancers of organs synthesizing steroidal hormones.
Claims18
A formulation of a therapeutic or diagnostic agent in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, wherein:
- the oily phase comprises:
- at least one amphiphilic lipid,
- at least one solubilizing lipid,
- at least one compound of the following formula (I):
- (R-L)n-A (I),
- wherein :
- n represents an integer from 1 to 5
- L represents a simple bond or a divalent group selected from —O—, —COO—, —OOC—, —CO—NR′—, —NR′—CO—, —S—, —NR′—CO—NR′—, —O—CO—O—,
- wherein R′ and R″ represent independently H or a linear or branched alkyl with 1 to 20 carbon atoms and
- R represents a linear or branched alkyl comprising at least 11 carbon atoms or a linear or branched alkenyl comprising at least 11 carbon atoms, and
- A represents a steriodic or sterolic group,
- and
- the aqueous phase includes at least one co-surfactant comprising at least one chain consisting of alkylene oxide units;
- the proportion of the compound of formula (I) being from 0.05% to 3% by weight based on the weight of the dispersed oily phase, the weight of the dispersed oily phase including the weight of the co-surfactant.
11 more elements
Dependencies are inferred from the claim text.