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US 9,707,281 B2Granted
Pharmaceutical compositions and methods for digesting atherosclerotic plaques
AssigneeNorthwestern University
InventorsMelina R. Kibbe, Guillermo A. Ameer, Vinit N. Varu
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Abstract
Disclosed are pharmaceutical compositions and methods for digesting atherosclerotic plaques in a patient in need thereof. The compositions include and the methods utilize a mixture of collagenases for digesting plaques and optionally may include or utilize additional agents such as cyclodextrins, chelating agents, and tissue plasminogen activator.
Claims11
A method for digesting a human arterial plaque within an artery of a patient the method comprising:
- (a) contacting the arterial plaque with a pharmaceutical composition comprising a collagenase mixture consisting of collagenase type I collagenase type III, collagenase type IV, and collagenase type V by administering the composition to the patient via a double-balloon catheter, wherein each of the collagenase type I, collagenase type III, collagenase type IV, and collagenase type
- V is present in the composition at a concentration of at least 0.5 mg/ml:
- and
- (b) applying ultrasonic energy at a frequency of 10-100 kHz to the arterial plaque during contacting the arterial plaque with the composition, wherein the ultrasonic energy is applied for u period of time sufficient to reduce mass of the arterial plaque by at least 30%.
1 more element
Dependencies are inferred from the claim text.