S1P receptors modulators and their use thereof

A method for treating a disease or condition caused by or associated with inappropriate S1P1 receptor modulating activity or expression, wherein the disease or condition is an immunological disorder and/or immune mediated disorder, which is a member selected from the group consisting of psoriasis, multiple sclerosis, ulcerative colitis, autoimmune encephalitis, influenza virus, stroke, sepsis, pain, arthritis, atopic dermatitis and vitiligo, by the administration of an effective amount of a compound of formula (II) or a stereoisomer and/or isotopic form or a pharmaceutically acceptable salt or derivative thereof, to a subject in need thereof,

• wherein
• B′ is a five-membered heterocyclic ring selected from one of the following:
• the asterisks indicating the attachment within formula (II);
• G represents
• R is selected from hydrogen, deuterium, alkylamino, CH2OH, alkoxy, a C1-5 alkyl chain optionally containing one or more of deuterium, O, NR′R″, S, and halogen, heterocycle, amide, sulphonamide, COOH, —OPO3H2, and —PO3H2,
• represents an optional bridging group;
• A ring is phenyl or pyridinyl;
• R2 independently is selected from halogen, hydrogen, deuterium, CN, amino, alkylamino, alkoxy, CF3, and a C1-4 alkyl chain optionally containing one or more of deuterium, OH, NR′R″, S, SO, SO2, a carbon-carbon double bond, a carbon-carbon triple bond, a carbon-heteroatom double bond, a carbon-hetero atom triple bond, carbocycle, heterocycle, amide, and sulphonamide;
• the groups J and D each are independently selected from hydrogen, deuterium, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, halogen, amino, hydroxy, cyano, aryl, heterocycle, carbocycle, and a C1-10 alkyl chain optionally containing a carbon-carbon multiple bond or a carbon-hetero multiple bond wherein one or more carbon atoms are optionally independently replaced with oxygen, sulphur, SO, SO2, NR′, carbocycle or heterocycle;
• and
• R′ and R″ each are independently selected from alkyl, cycloalkyl, aryl, and heterocycle, to treat the disease or condition.