Vaccines for use in the prophylaxis and treatment of influenza virus disease
AssigneeIcahn School of Medicine at Mount Sinai
InventorsAdolfo Garcia-Sastre, Peter Palese, Taia T. Wang, Gene S. Tan
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Abstract
Provided herein are polypeptides comprising portions of the influenza virus hemagglutinin, compositions comprising such polypeptides that can be used as immunogens in vaccines and methods of their use to generate an immune response against multiple influenza subtypes in a subject.
Claims23
An immunogenic composition capable of inducing antibodies that are cross-reactive among influenza hemagglutinin (HA) subtypes, the immunogenic composition comprising a flu polypeptide comprising an immunogenic core polypeptide, wherein the immunogenic core polypeptide is (a) directly or indirectly linked at its N- and/or C-terminus to one or more tags;
- (b) directly or indirectly linked at its N- and/or C-terminus to a T cell epitope;
- (c) directly or indirectly linked at its N- and/or C-terminus to a Toll Like Receptor ligand;
- or (d) directly or indirectly linked at its N- and/or C-terminus to a T4 foldon domain or a fragment thereof, wherein the immunogenic core polypeptide is less than 75 amino acids in length, and wherein the immunogenic core polypeptide comprises:
- R-I-Q-D-L-E-K-Y-V-E-D-T-K-I-D-L-W-S-Y-N-A-E-L-L-V-A-L-E-N-Q-H-T-I-D-L-T-D-S-E-M-N-K-L-F-E-X1T-X2-X3-Q-L-R-E-N-A (SEQ ID NO:
- 15), wherein X1, X2, and X3 are hydrophilic, basic amino acids.
Dependencies are inferred from the claim text.