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AssigneeVertex Pharmaceuticals Incorporated
InventorsMark Strohmeier, John Caesar, Jr., Patrick Raymond Connelly, Majed Fawaz, Eduard Luss-Lusis, Brian McClain, Ales Medek, Hai Miao, Kwame Wiredu Nti-Addae, Ping Yin, Yuegang Zhang
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The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.
A pharmaceutical composition comprising a co-crystal of Compound 1 and only one triglyceride, wherein the triglyceride is chosen from the following structural formula:
A pharmaceutical composition comprising a therapeutically effective amount of Compound 1 and a pharmaceutically acceptable carrier or excipient, wherein Compound 1 is represented by the following structural formula:
A method of preparing a co-crystal comprising Compound 1 and a triglyceride,
Dependencies are inferred from the claim text.